Flashcards in Immunology 5: Inflammatory dematoses Deck (51)
What is the role of melanin in the skin?
Protect keratinocyte nuclei from damage
Recall the life cycle of a keratinocyte
Originates in BM
Migrates supradermally, producing keratin
Dead and anucleated by the time they reach stratum corneum
Form "bricks" in barrier of skin ("cement" = lipids)
Recall the general pathophysiology of eczema
Defect in barrier function of skin
Recall the types of sweat gland, and the type of secretion they produce
Eccrine - watery
Apocrine - viscous
What are the 2 main components of the matrix in the dermis?
Which part of the skin is affected by acne?
Summarise the pathogensis of acne
1. Androgenic stimulation
2. Sebaceous gland hypertrophy
3. Accumulation of sebum and keratin
What are black and white heads and what is the proper term given to them?
Black head = buildup of sebum + keratin at the infundibulum = open comedone
White head = black head with skin on top = closed comedone
What are the main areas affected by acne?
By what other name is eczema known?
Which of the common skin conditions are classed as atopic?
Recall how eczema tends to affect individuals over their lifetime
Tends to start young and go away by adulthood
Fist step in atopic march
Why doe seczema predispose to other atopic diseases?
Defective barrier function of the skin allows infiltration of other allergens
Recall 3 things that may enter the body through the skin due to eczema
What is the main pathogen involved in skin infection?
What is the function of the filagrin protein?
Maintains barrier function
What is palmar hyperlinearity a sign of?
What are the worst-affected areas by eczema on a baby?
What are the worst-affected areas by eczema in adults?
Where there is sweat - eg antecubital fossa
Recall 4 types of eczema
What type of skin disease is dandruff?
Mild seborrheic eczema
Recall the pathogenesis of eczema herpeticum
HSV able to penetrate skin due to defective barrier
Recall which areas are most commonly affected in severe seborrheic eczema
Recall the pathogenesis of seborrheic eczema
Overgrowth of naturally-occurring yeast on skin and a secondary dermatitis reaction to this
Recall 2 common allergens that can cause ACD
PPD in black henna
Where is the most common site affected by discoid eczema?
What is the main treatment for discoid eczema?
What is the primary form of inflammatory dermatosis?
Recall 4 types of psoriasis
Generalised pustular psoriasis