Immunology 5: Inflammatory dematoses Flashcards Preview

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Flashcards in Immunology 5: Inflammatory dematoses Deck (51)
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1

What is the role of melanin in the skin?

Protect keratinocyte nuclei from damage

2

Recall the life cycle of a keratinocyte

Originates in BM
Migrates supradermally, producing keratin
Dead and anucleated by the time they reach stratum corneum
Form "bricks" in barrier of skin ("cement" = lipids)

3

Recall the general pathophysiology of eczema

Defect in barrier function of skin

4

Recall the types of sweat gland, and the type of secretion they produce

Eccrine - watery
Apocrine - viscous

5

What are the 2 main components of the matrix in the dermis?

Collagens
GAGs

6

Which part of the skin is affected by acne?

Pilosebaceous unit

7

Summarise the pathogensis of acne

1. Androgenic stimulation
2. Sebaceous gland hypertrophy
3. Accumulation of sebum and keratin

8

What are black and white heads and what is the proper term given to them?

Black head = buildup of sebum + keratin at the infundibulum = open comedone
White head = black head with skin on top = closed comedone

9

What are the main areas affected by acne?

Face
Neck
Upper back
Upper chest

10

By what other name is eczema known?

Dermatitis

11

Which of the common skin conditions are classed as atopic?

Eczema
Acne

12

Recall how eczema tends to affect individuals over their lifetime

Tends to start young and go away by adulthood
Fist step in atopic march

13

Why doe seczema predispose to other atopic diseases?

Defective barrier function of the skin allows infiltration of other allergens

14

Recall 3 things that may enter the body through the skin due to eczema

Allergens
Irritants
Pathogens

15

What is the main pathogen involved in skin infection?

Staphylococcus aureus

16

What is the function of the filagrin protein?

Epidermal protein
Maintains barrier function

17

What is palmar hyperlinearity a sign of?

Filagrin mutation

18

What are the worst-affected areas by eczema on a baby?

Cheeks
Elbows
Knees

19

What are the worst-affected areas by eczema in adults?

Where there is sweat - eg antecubital fossa

20

Recall 4 types of eczema

Eczema herpeticum
Seborrheic
Allergic-contact dematitis
Discoid

21

What type of skin disease is dandruff?

Mild seborrheic eczema

22

Recall the pathogenesis of eczema herpeticum

HSV able to penetrate skin due to defective barrier

23

Recall which areas are most commonly affected in severe seborrheic eczema

Nasolabial folds
eyebrows
forehead

24

Recall the pathogenesis of seborrheic eczema

Overgrowth of naturally-occurring yeast on skin and a secondary dermatitis reaction to this

25

Recall 2 common allergens that can cause ACD

Makeup
PPD in black henna

26

Where is the most common site affected by discoid eczema?

Legs

27

What is the main treatment for discoid eczema?

Emoliant

28

What is the primary form of inflammatory dermatosis?

Psoriasis

29

Recall 4 types of psoriasis

Chronic plaque
Guttate
Palmoplantar pustulosis
Generalised pustular psoriasis

30

Recall a common comorbidity that presents with psoriasis

Psoriatic arthritis