Immunology 5 - SSN

Question 1

What do the inferons do, and what pathway activates them?

Answer 1

1) break down RNA
2) recruit adaptive immunity
3) increase MHC I expression
Activated by TLR and NLR via NF-kB and IRF pathways.

Question 2

What are the classic encapsulated pathogens (with an acronym)?

Answer 2

SHINS
Strep Pneumo
H. Influenza
Nisseria
Salmonella

Question 3

What causes chronic granulomatous disease and what pathogens take advantage?

Answer 3

Defect in NADPH oxidase. Leads to lots of staph infections.

Question 4

What type of allergic reaction is atopic dermatitis? What causes it? What is the criteria?

Answer 4

1) Type I hypersensitivity
2) Filaggrin gene
3) Dee 3 of following:
pruritus (itching); personal or family history of atopic derm, chronic or relapsing derm, typical morphology.

Question 5

What type of allergic reaction is contact dermatitis?

Answer 5

Type IV, requires sensitization, allergic such as poison ivy, nickel, fragrances.

Question 6

What does Bortezomib do?

Answer 6

Proteasome inhibitor, used to treat multiple myeloma.