Immunology

Question 1

Celiac nodes

Answer 1

Liver
Stomach
Spleen
Pancreas
Upper duodenum

Question 2

Superior mesenteric

Answer 2

Lower duodenum
Jejenum
Ileum
Colon to splenic flexure

Question 3

Inferior mesenteric

Answer 3

Colon from splenic flexure to upper rectum

Question 4

Internal iliac

Answer 4

Lower rectum to above pectinate line of anal canal
Bladder
Vagina middle third
Cervix
Prostate

Question 5

Para aortic

Answer 5

Tested
Ovaries
Kidneys
Uterus

Question 6

Superficial inguinal

Answer 6

Anal canal below pectinate line
Skin below umbilicus except popliteal
Scrotum
Vulva

Question 7

Popliteal

Answer 7

Dorsolateral foot

Post calf

Question 8

R lymphatic duct drains

Answer 8

R side of body above diaphragm

Thoracic duct drains everything else into junction of l subclavian and internal jugular veins

Question 9

Encapsulated organisms

Please SHINE my SKiS

Answer 9

Pseudomonas 
Strep pneumonia 
H Influenza
Neisseria meningitis 
E. coli
Salmonella 
Klebsiella
Group B Strep

Question 10

Post splenectomy on blood smear

Answer 10

Howell Jolly bodies
Target cells
Thrombocytosis
Lymphocytosis

Question 11

HLA A3

Answer 11

Haemochromatosis

Question 12

HLA B8

Answer 12

Addison disease

MG

Question 13

HLA B27

Answer 13

PAIR

Question 14

HLA DQ2/8

Answer 14

Celiac disease

Question 15

HLA DR2

Answer 15

MS
SLE
hay fever
Goodpastures

Question 16

HLA DR3

Answer 16

DM1
SLE 
Graves
Hashimotos
Addison

Question 17

HLA DR4

Answer 17

RA
DM1
Addison disease

Question 18

HLA DR5

Answer 18

Pernicious anaemia B12 def

Hashimotos

Question 19

T cell activation

Answer 19

Signal 1
MHC 2 APC recognised by TCR on CD4 cells. Antigen presented on MHC 1 to CD8 cells

Signal 2
Costim B7 (Cd80/86) and CD28

Question 20

B cell activation

Answer 20

Antigen on MHC 2 recognised by Th cell.

CD40 receptor on B cell binds with CD40L on Th cell

Question 21

Naive B cells express

Answer 21

IgM IgD

Question 22

IgG

Answer 22

Delayed response
MC in serum
Crosses placenta

Question 23

IgA

Answer 23

GIT Peyer patches
Most produced AB
Secretions and breast milk

Question 24

IgM

Answer 24

Immediate
Monomer on B cell
Pentamer with J chain

Question 25

IgE

Answer 25

Type 1 HS Histamine Eosinophils

Question 26

Cytokines secreted from macrophages

Answer 26

``` IL 1 IL 6 IL 8 IL 12 TNFa ```

Question 27

Cytokines secreted from all T cells

Answer 27

IL 2 | IL 3

Question 28

Cytokines secreted from Th1 cells

Answer 28

IFNy

Question 29

Cytokines secreted from Th2 cells

Answer 29

IL4 IL5 IL10

Question 30

Hot T bone stEAK

Answer 30

``` IL 1 fever = hot IL2 stimulates T cells IL3 stimulates bone marrow IL4 stimulates IgE production IL5 stimulates IgA production IL6 stimulates aKute phase protein production ```

Question 31

IL 8 Clean up on aisle 8

Answer 31

Neutrophils recruited to clear infections

Question 32

IL 12

Answer 32

T cells —> Th1 cells | Activate NK cells

Question 33

TNFa

Answer 33

Septic shock Activates endothelium Causes WBC recruitment vascular leak Cachexia

Question 34

IFNy

Answer 34

Macrophages —> IL 12 —> NK and T cells —> IFNy —>macrophages to kill phagocytosis pathogens

Question 35

IL 10 and TGF-B

Answer 35

atTenuate/ regulate immune system

Question 36

MHC 1 on all nucleated cells but not

Answer 36

Mature RBCs

Question 37

TCR CD3 CD28 CXCR4 / CCR5

Answer 37

T cells

Question 38

CD4 | CD40L

Answer 38

Helper T cells

Question 39

CD8 CXCR4 CCR5

Answer 39

Cytotoxic T cells

Question 40

CD4 | CD25

Answer 40

Regulatory T cells

Question 41

Ig CD19/ 20/ 21 (EBV) / 40 MHC 2 B7

Answer 41

B cells

Question 42

``` CD14 CD40 CCR5 MHC II B7 (CD80/86) Fc and C3b receptors ```

Answer 42

Macrophages

Question 43

CD16 binds F.C. of IgG | CD56

Answer 43

NK cells

Question 44

CD34

Answer 44

Hematopoietic stem cells

Question 45

Superantigens = S pyogenes/ aureus Endotoxins/LPS =?

Answer 45

GNB

Question 46

Antigenic variation

Answer 46

Bacteria Salmonella Borrelia recurrentis Influenza HIV HCV Trypanosomes

Question 47

Passive immunisation

Answer 47

``` Tetanus toxin Botulinum toxin HBV Varicella Rabies ``` Give antibodies to unvaccinated after exposure

Question 48

Live attenuated vaccine

Answer 48

``` BCG Influenza Measles Mumps Polio Rubella Varicella Yellow fever ```

Question 49

Inactivated or killed vaccine

Answer 49

Rabies Influenza injections Polio Salk Hepatitis A

Question 50

HS types

Answer 50

ACID Anaphylactic and Atopic Cytotoxic AB mediated Immune complex Delayed cell mediated