Pathology

Question 1

Male cancer incidence

Answer 1

Prostate
Lung
Colon

Question 2

Female cancer incidence

Answer 2

Breast
Lung
Colon

Question 3

Male cancer mortality

Answer 3

Lung
Prostate
Colon

Question 4

Female cancer mortality

Answer 4

Lung
Breast
Colon

Question 5

Skin cancer types by frequency

Answer 5

Basal > squamous > melanoma

Question 6

Acanthosis nigricans a/w

Answer 6

Gastric adenocarcinoma
Obesity
Insulin resistance

Question 7

Leser-Trelat sign a/w

Answer 7

GI adenocarcinoma

Question 8

Trousseau sign is migratory superficial thrombophlebitis a/w

Answer 8

Adenocarcinoma, pancreatic

Question 9

Lambert Eaton
A/w
Antibodies against

Answer 9

Small cell lung cancer

Presynaptic P/Q type calcium channels at NMJ

Question 10

Myasthenia gravis
A/w
Antibodies against

Answer 10

Thymoma

Postsynaptic AChR at NMJ

Question 11

Haematogenous spread of sarcomas and 4 carcinomas

Answer 11

HCC
Renal cell
Follicular thyroid
Choriocarcinoma

Question 12

Mets to brain from

Answer 12

Lung
Breast
Prostate
Melanoma
GI

Question 13

Mets to liver

Answer 13

Colon
Stomach
Pancreas

Question 14

Mets to bone

Answer 14

Prostate breast

Lung thyroid kidneys

Question 15

ALP

Answer 15

Mets to bone or liver
Paget disease of bone
Seminoma

Question 16

aFP

Answer 16

HCC
hepatoblastoma
Yolk sac
Mixed germ cell

Question 17

B-hCG

Answer 17

Hydatiform moles
Choriocarcinoma
Testicular cancer
Mixed germ cell tumour

Question 18

CA 15-3/27-29

Answer 18

Breast cancer

Question 19

CA19-9

Answer 19

Pancreatic adenocarcinoma

Question 20

CA125

Answer 20

Ovarian cancer

Question 21

Calcitonin

Answer 21

Medullary thyroid cancer

Question 22

CEA

Answer 22

Colorectal 
Pancreatic 
Gastric
Breast
Medullary thyroid

Question 23

Psammoma bodies in PSMM

Answer 23

Papillary thyroid
Serous cyst adenocarcinoma ovary
Meningioma
Malignant mesothelioma

Question 24

Carbon tetrachloride

Answer 24

Centrilobular necrosis

Fatty change

Question 25

Asbestos

Answer 25

Bronchogenic ca | Mesothelioma

Question 26

Aflatoxins from aspergillus

Answer 26

HCC

Question 27

WT1/WT2

Answer 27

Wilms tumour

Question 28

VHL inhibits

Answer 28

Hypoxia inducible factor 1a

Question 29

P53 activates p21 and blocks G1-S phase. | What other TSG blocks this phase?

Answer 29

Rb, inhibits E2F

Question 30

PTEN TSG

Answer 30

Breast Prostate Endometrial cancer

Question 31

NF2 product

Answer 31

Merlin schwannomin protein

Question 32

NF1

Answer 32

Ras GTPase activating protein / neurofibromin

Question 33

DCC TSG

Answer 33

Colon cancer

Question 34

CDKN2A TSG

Answer 34

Melanoma | Pancreatic cancer

Question 35

ALK

Answer 35

Receptor tyrosine kinase Lung adenocarcinoma

Question 36

BCR-ABL

Answer 36

Tyrosine kinase CML ALL

Question 37

BCL-2

Answer 37

Anti apoptosis Follicular and diffuse large B cell lymphoma

Question 38

BRAF

Answer 38

Serine/threonine kinase Melanoma Nonhodgkin lymphoma

Question 39

c-KIT

Answer 39

Cytokine receptor GIST

Question 40

c-MYC

Answer 40

Transcription factor Burkitt lymphoma

Question 41

HER2

Answer 41

Tyrosine kinase Breast Gastric

Question 42

JAK2

Answer 42

Tyrosine kinase Chronic myeloproliferative disorders

Question 43

KRAS

Answer 43

GTPase Colon Lung Pancreatic

Question 44

MYCL1 and MYCN are transcription factors in Lung and Neuroblastoma. What cancers is the tyrosine kinase oncogene RET a/w?

Answer 44

MEN 2A, 2B | Medullary thyroid