What is an antigen?
Any molecule that can be specifically recognized by the specific immune system
What is an antibody?
Specific Ig produced by a specific B cell that recognizes and binds to specific antigens that are recognized as non-self
Where does the thymus develop from?
Third and fourth pharyngeal pouches
How is the thymus critical for the immune system?
Critical for major histocompatibility complex restriction (MHC) which is imposed on lymphoid precursors arising form the yolk sac, fetal liver, and bone marrow
Where do T-cells develop?
What are the members of the secondary lymphoid system?
Waldeyer ring, lymph nodes, spleen, mucosa-associated lymphoid tissue
Where are B-cells primarily found in the lymph node?
Cortex and medulla
Where are T-cells primarily found in the lymph node?
Paracortex and medulla
What kind of Ig is produced by MALT?
CD2 and CD3 differentiate what types of cells?
Which types of T-cells have CD4?
What are helper T-cells responsible for?
Augmenting the interactions between T-T, T-B, and T-macrophage cells
Allergic inflammation is characterized by a TH1 or a TH2 response?
What do TH1 cells produce?
IL-2 and IFN-gamma
Do TH1 cells stimulate or inhibit B-cells?
What do TH2 cells produce?
IL-4, 5, 6, and 10
Do TH2 cells stimulate or inhibit B-cells?
CD8 T-cells function by doing what?
Specific killing of target cells, inhibit the response of B-cells and other T-cells
Which MHCs are associated with helper T-cells?
What MHCs are associated with cytotoxic T-cells?
In order for proper antigen recognition, what must an antigen be presented with?
MHC on the antigen-presenting cell
What induces proliferation of both T- and B-cells?
What type of MHC is on the surface of B-cells?
MHC Class II
Which CD molecules are on B-cells?
CD 19, 20, 22
What is the purpose of NK cells?
Eliminate cells that become spontaneously malignant or are infected with virus
What type of receptors are on NK cells?
Which CD molecules are on NK cells?
CD 16, 56
What is the principle function of the MHC?
Bind fragments of foreign protein to form complexes recognized by T-cells
How are endogenous antigens processed?
Pass through rough endoplasmic reticulum and are associated with MHC Class I molecules
How are exogenous antigens processed?
Hydrolyzed and associated with MHC Class II molecules