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Flashcards in Immunology/Allergy Deck (131)
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1

What is an antigen?

Any molecule that can be specifically recognized by the specific immune system

2

What is an antibody?

Specific Ig produced by a specific B cell that recognizes and binds to specific antigens that are recognized as non-self

3

Where does the thymus develop from?

Third and fourth pharyngeal pouches

4

How is the thymus critical for the immune system?

Critical for major histocompatibility complex restriction (MHC) which is imposed on lymphoid precursors arising form the yolk sac, fetal liver, and bone marrow

5

Where do T-cells develop?

Thymus

6

What are the members of the secondary lymphoid system?

Waldeyer ring, lymph nodes, spleen, mucosa-associated lymphoid tissue

7

Where are B-cells primarily found in the lymph node?

Cortex and medulla

8

Where are T-cells primarily found in the lymph node?

Paracortex and medulla

9

What kind of Ig is produced by MALT?

Secretory IgA

10

CD2 and CD3 differentiate what types of cells?

All T-cells

11

Which types of T-cells have CD4?

Helper T-cells

12

What are helper T-cells responsible for?

Augmenting the interactions between T-T, T-B, and T-macrophage cells

13

Allergic inflammation is characterized by a TH1 or a TH2 response?

TH2

14

What do TH1 cells produce?

IL-2 and IFN-gamma

15

Do TH1 cells stimulate or inhibit B-cells?

Inhibit

16

What do TH2 cells produce?

IL-4, 5, 6, and 10

17

Do TH2 cells stimulate or inhibit B-cells?

Stimulate

18

CD8 T-cells function by doing what?

Specific killing of target cells, inhibit the response of B-cells and other T-cells

19

Which MHCs are associated with helper T-cells?

MHC II

20

What MHCs are associated with cytotoxic T-cells?

MHC I

21

In order for proper antigen recognition, what must an antigen be presented with?

MHC on the antigen-presenting cell

22

What induces proliferation of both T- and B-cells?

IL-1

23

What type of MHC is on the surface of B-cells?

MHC Class II

24

Which CD molecules are on B-cells?

CD 19, 20, 22

25

What is the purpose of NK cells?

Eliminate cells that become spontaneously malignant or are infected with virus

26

What type of receptors are on NK cells?

IgG receptors

27

Which CD molecules are on NK cells?

CD 16, 56

28

What is the principle function of the MHC?

Bind fragments of foreign protein to form complexes recognized by T-cells

29

How are endogenous antigens processed?

Pass through rough endoplasmic reticulum and are associated with MHC Class I molecules

30

How are exogenous antigens processed?

Hydrolyzed and associated with MHC Class II molecules