Immunology--Autoantibodies Flashcards Preview

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Flashcards in Immunology--Autoantibodies Deck (23):
1

Anti-ACh receptor

Myasthenia gravis

2

Anti-basement membrane

Goodpasture syndrome

3

Anticardiolipin, lupus anticoagulant

SLE, antiphospholipid syndrome

4

Anticentromere

Limited scleroderma (CREST syndrome)

5

Anti-desmosome (anti-desmoglein)

Pemphigus vulgaris

6

Anti-dsDNA, Anti-Smith

SLE

7

Anti-glutamic acid decarboxylase (GAD-65)

Type I DM

8

Antihemidesmosome

Bullous pemphigoid

9

Anti-histone

Drug-induced lupus

10

Anti-Jo-I, anti-SRP, anti-Mi-2

polymyositis, dermatomyositis

11

Antimicrosomal, antihyroglobulin

Hashimoto thyroiditis

12

Antimitochondrial

primary biliary cirrhosis

13

Antinuclear antibodies

SLE, nonspecific

14

Antiparietal cell

Pernicious anemia

15

Anti-Scl-70 (anti-DNA topoisomerase)

Scleroderma (diffuse)

16

Anti-smooth muscle

Autoimmune hepatitis

17

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Sjogren syndrome

18

Anti-TSH receptor

Graves disease

19

Anti-U1 RNP (ribonucleoprotein)

Mixed connective tissue disease

20

IgA anti-endomysial, IgA anti-tissue transglutaminase

Celiac disease

21

MPO-ANCA/p-ANCA

Microscopic polyangitis, eosinophilic granulmatosis with polyangitis (Churg-Strauss syndrome)

22

c-ANCA/ PR3-ANCA

Granulomatosis with polyangiitis (Wegener)

23

Rheumatoid factor (IgM antibody that targets IgG Fc region), anti-CCP (more specific)

Rheumatoid arthritis