Immunology First Two Lectures

Question 1

What is the name for a type 1 hypersensitivity reaction?

Answer 1

Anaphylactic

Question 2

What are the characteristics of a type 1 hypersensitivity reaction?

Answer 2

Wheal and flare

Question 3

What antibody is involved in a type 1 hypersensitivity reaction?

Answer 3

IgE

Question 4

What WBCs are involved in a type 1 hypersensitivity reaction?

Answer 4

Eosinophils and Basophils

Question 5

What is the name for a type 2 hypersensitivity reaction?

Answer 5

Cytotoxic

Question 6

What are the characteristics of a type 2 hypersensitivity reaction?

Answer 6

Cell lysis and necrosis

Question 7

What antibody is involved in a type 2 hypersensitivity reaction?

Answer 7

IgG and IgM

Question 8

What immune processes are involved in a type 1 hypersensitivity reaction?

Answer 8

Antibodies and compliment system

Question 9

Give an example of a type 2 hypersensitivity reaction

Answer 9

Good pastures

Question 10

What is the name for a type 3 hypersensitivity reaction?

Answer 10

Immune complex

Question 11

What are the characteristics of a type 3 hypersensitivity reaction?

Answer 11

Errythema oedema and necrosis

Question 12

What antibody is involved in a type 3 hypersensitivity reaction?

Answer 12

IgG and IgM

Question 13

What immune factors are involved in a type 3 hypersensitivity reaction?

Answer 13

Neutrophils and complement system

Question 14

Give an example of a type 3 hypersensitivity reaction

Answer 14

Farmers Lung

SLE

Question 15

What is the name for a type 4 hypersensitivity reaction?

Answer 15

Delayed type

Question 16

What antibody is involved in a type 4 hypersensitivity reaction?

Answer 16

None

Question 17

What are the characteristics of a type 4 hypersensitivity reaction?

Answer 17

Erythema

Question 18

Give an example of a type 4 hypersensitivity reaction

Answer 18

Contact dermatitis

TB

Question 19

What is the atopic triad

Answer 19

Allergic Rhinitis
Asthma
Atopic dermatitis

Question 20

What does release of IgE do to the body

Answer 20

Smooth muscle hypertrophy
Vasodilation
Mucous glands activated

Question 21

What is the late phase response?

Answer 21

After histamine has been released

Cytokines are released and leukotrienes and prostaglandins

Question 22

Whats the gold standard test for food allergies

Answer 22

Oral challenge test

Question 23

What other tests can you can do for allergies

Answer 23

Basophil activation test (when IgE binds to basophils Cd63 markers increase)
Skin prick test

Question 24

Name the three phagocytotic cells

Answer 24

Neutrophils (eat)
Macrophages (eat and produce chemokine)
Dendritic cells (eat and present antigen to T cell)

Question 25

What system is involved in autoinflammation?

Answer 25

Innate immune system - Neutrophils and macrophages

Question 26

What system is involved in autoimmune disease?

Answer 26

Adaptive

Question 27

What is central tolerance?

Answer 27

When B and T cells are made in BM they mature and undergo negative selection in the thymus to ensure they don't fight the body

Question 28

What does a mutation in the FOXP3 gene do?

Answer 28

Causes failure to develop regulatory T cells | Causes severe autoimmunity from birth

Question 29

In AI diseases what do auto reactive B and T cells do?

Answer 29

Autoreative B cells: activate autoantibodies and the complement system Autoreactive T cells: Activate Cytokines