Immunology / Pathology

Question 1

Transplant Rejection Morphology: Gross mottling and Cyanosis

Answer 1

Hyperacute

Question 2

Transplant Rejection Morphology: Arterial fibrinoid necrosis + Capillary Thrombotic Occlusion

Answer 2

Hyperacute

Question 3

Transplant Rejection Morphology: C4d deposition

Answer 3

Acute (Humoral)

Question 4

Transplant Rejection Morphology: Neutrophilic infiltrate

Answer 4

Acute (Humoral)

Question 5

Transplant Rejection Morphology: Necrotizing vasculitis

Answer 5

Acute (Humoral)

Question 6

Transplant Rejection Morphology: Lymphocytic interstitial infiltrate

Answer 6

Acute (Cellular)

Question 7

Transplant Rejection Morphology: Endotheliitis

Answer 7

Acute (Cellular)

Question 8

Transplant Rejection Morphology: Chronic (4)

Answer 8

1) Vascular wall thickening
2) Vascular luminal narrowing
3) Interstitial Fibrosis
4) Parenchyma atrophy

Question 9

CP: Serum Sickness Drug Hypersensitivity Reaction
Onset:

Answer 9

CP: fever / urticaria / arthralgia / proteinuria / LAD
Onset: 5-10 days after exposure

Question 10

Fxn: Bradykinin

Answer 10

vasodilation / increase vascular permeability / stimulate nonvascular smooth muscle contraction / mediates pain

Question 11

Fxn: C3a (2)

Answer 11

C3a / C4a / C5a are inflammatory anaphylotoxis that trigger histamine release from mast cells

C3a recruits and activates eosinophils and basophils (BUT NOT neutrophils)

Question 12

IL-3

Answer 12

Produced by activated T cells

Stim. growth and differentiation of stem cells in bone marrow

Question 13

IL-10

Answer 13

TH2 cells + Macrophage

Anti-inflammatory: decrease IFN gamma / IL-2 / IL-3 / TNF-alpha

Question 14

Leukotriene C4, D4 , E4

Answer 14

vasoconstriction
increase vascular permeability
bronchospasm

Question 15

Neutrophil chemotaxis

Answer 15

n-formylated peptide
5-HETE (leukotriene precursor)
C5-a
LTB4
IL-8