Microbio

Question 1

CP: C. diff

Answer 1

Fever / Abd Pain / Watery Diarrhea (with or without blood)/ LEUKOCYTOSIS

Question 2

Anthrax Exotoxin: Edema Factor

Answer 2

Act as an Adenylate Cyclase –> Increase cAMP

- Cause edema and phagocyte dysfunction

Question 3

Anthrax Exotoxin: Lethal Factor

Answer 3

A zinc dependent protease - inhibits mitogen activated protein kinase signaling
- Cause: Apoptosis and Multisystem physiologic disruption

Question 4

Pertussis Toxin

Answer 4

Disinhibits AC through Gi ADP-ribosylation
Result: Increase cAMP
- Cause: Edema and Phagocytic dysfunction

Question 5

Adenylate Cyclase Toxin

Answer 5

Secreted by B. pertussis
Functions as AC –. increase cAMP
- Cause: Edema and Phagocytic dysfunction

Question 6

C. diff: Toxin A

Answer 6

Recruits and Activates neutrophils

- leading to release of cytokines –> Mucosal inflammation / fluid loss / diarrhea

Question 7

C. diff Toxin B

Answer 7

Induces actin depolymerization –> Mucosal death / Bowel wall necrosis / Pseudomembrane formation

Question 8

Pyrogenic Exotoxin

Answer 8

S. Pyogenes:
Acts as a superantigen
Induce fever and shock
Associated with Scarlet fever and Streptococcal TSS

Question 9

Streptolysin OandS

Answer 9

Damages erythrocytes membranes causing beta hemolysis