Important Cytokines Flashcards Preview

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Flashcards in Important Cytokines Deck (11):
1

Interleukin-1
(IL-1)

Secreted by macrophages
An endogenous pyrogen, also called osteoclast-activating factor.
Causes fever, acute inflammation.
Activates endothelium to express adhesion molecules;
Induces chemokine secretion to recruit leukocytes

2

Interleukin-6
(IL-6)

Secreted by macrophages and Th2 Cells
Endogenous pyrogen
Causes fever
Stimulates production of acute-phase proteins

3

Interleukin-8
(IL-8)

Secreted by macrophages
Major chemotactic factor for neutrophils

"Clean up on aisle 8"
=> Neutrophils are recruited by IL-8 to clear infections

4

Interleukin-12
(IL-12)

Secreted by macrophages and B cells
Induces differentiation of T cells into Th1 Cells
Activates NK cells

5

Tumor Necrosis Factor-alpha
(TNF-alpha)

Secreted by macrophages
Mediates septic shock
Activates endothelium
Causes leukocyte recruitment and vascular leak

6

Interleukin-2
(IL-2)

Secreted by all T cells
Stimulates growth of helper, cytotoxic, and regulatory T cells

"T cell stimulator"

7

Interleukin-3
(IL-3)

Secreted by all T cells
Supports the growth and differentiation of bone marrow stem cells.
Functions like GM-CSF

8

Interferon-gamma
(IFN-gamma)

Secreted by Th1 cells
Has antiviral and antitumor properties.
Activates NK cells to kill virus-infected cells
Increases MHC expression
Increases antigen presentation in all cells

"Macrophage stimulator"

9

Interleukin-4
(IL-4)

Secreted by Th2 cells
Induces differentiation into Th2 cells
Promotes growth of B cells
Enhances class switching to IgE and IgG

"B cell stimulator"

10

Interleukin-5
(IL-5)

Secreted by Th2 cells
Promotes differentiation of B cells
Enhances class switching to IgA
Stimulates the growth and differentiation of eosinophils

"B cell stimulator"

11

Interleukin-10
(IL-10)

Secreted by Th2 cells and regulatory T cells
Modulates inflammatory response
Inhibits actions of activated T cells
Inhibits actions of activated Th1 cells

Has similar actions to TGF-beta, since both are involved in inhibiting inflammation