Indapamide

Question 1

What class of drug is indapamide?

Answer 1

Thiazide or thiazide like diuretic

Question 2

MOA

Answer 2

Blocks NaCl channel in distal convoluted tubule.
Water follows osmotic gradient and so is released in urine

Question 3

Drug-drug interactions?

Answer 3

Alcohol
Amlodipine
Both increase risk of hypertension, but if find balance (most important when prescribing diuretics) can prescribe

Question 4

Important adverse drug reactions?

Answer 4

Hypokalaemia- as NaCl channel blocked, more Na is taken in at ENaC challenge further downstream so more ROMK too, more potassium leaves body
Hyperuricaemia-
Hyperglycaemia-
Erectile dysfunction-
Inc LDL inc TAG
Hypercalcaemia- NaCl channel blocked. NaCa channel is favoured. More calcium entering bloodstream

Question 5

Common indications?

Answer 5

Hypertension
Heart failure
Oedema
2° hypoaldosteronism nephrotic syndrome
CKD
Decompensating liver disease