Infection Flashcards
(20 cards)
Hepatitis E mechanism of spread
Faecal-oral route
Hep E incubation period
3-8 weeks
What type of hepatitis would be severe in a pregnant woman?
Hep E
Which viral hepatitis does not cause increased level of HCC?
Hep E
Hepatitis A background
Self-limiting disease - severe outcomes rare
Spread by faecal-oral route
Incubation = 2-4 wks
Clinical features of Hep A
Flu-like pro-drome
RUQ pain
Jaundice
Tender hepatomegaly
Deranged LFTs
Hep A vaccination
Give initial dose
Booster 6-12mths later
Hep B - Mode of transmission
Blood borne
Vertical transmission
incubation period = 6 - 20 weeks
Features Hep B
Jaundice, fever, elevated liver transaminases
Mx Hep B
Pegylated interferon A
Tenofovir, entecavir, telbivudine
Antibody titres for hep B
> 100 - adequate response, booster 5 yrs
10-100 - need 1 additional vaccine
<10 - no response
need to test for previous infection/immunity
Then give 3 doses vaccine again, then give booster + HBIg when exposed to virus
Complications of Hep B
Chronic viral hepatitis - ground glass appearance on light microscopy
Fulminant liver failure
HCC
Polyarteritis nodosa
Can hep B be transmitted via breastfeeding?
No
C-section does not reduce vertical transmission rates
Who to give complete course of vaccination + Hep B immunoglobulin
Babies w/ chronic hep B infection
Mothers had acute hep b during pregnancy
Hep C
IVDU
6-9 weeks incubation period
No vaccine
risk of vertical transmission - 6%
After acute infection many will go on to develop chronic hep C
features of hep c infection
Jaundice
Deranged transaminase
Arthralgia
Diagnosis acute hep c infection
HCV RNA
Definition of chronic Hep C
HCV RNA in blood >6mths
Mx chronic hep C
Daclatasvir + sofosbuvir
Sofosbuvir + simeprivir
+/- ribavarin
Aim to reach undetectable serum HCV RNA in blood 6mths after end of treatment
Complications chronic hep c
Cirrhosis
Hepatocellular carcinoma
Cryoglobulinaemia
Rheumatological problems
Eye problems
Sjrojen’s syndrome
