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Flashcards in Infectious Deck (89)
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1

Organism produces exotoxin and inhibits protein synthesis and causes gray-brown adherent pseudomembrane to bleeding edematous submucosa

Corynebacterium diphtheria

2

Bull neck appearance, leather like adherent membrane (pseudomembrane)

Corynebacterium diphtheria

3

Difference of diphtheria from strep throat

Relative lack of fever
Non-exudative throat

4

Period of communicability of pertussis

7 days after exposure to 4 weeks after onset of paroxysms

Catarrhal stage

5

Conjunctival suffusion, petechiae on upper anterior chest, clear breath sound, whooping cough

In between paroxysms child is well looking

Pertussis

6

Abrupt onset of fever, chills, headache, vomiting

Rapid worsening of symptoms within hours

Initially morbiliform rash becoming petechial then purpuric within hours

Meningococcemia

7

Drug of choice for Meningococcemia

Penicillin G 250000 - 300000 U/kg/day

8

CSF FINDINGS in Meningitis:

Pressure: 100-300mmHg
WBC: 100-10,000
CHON: 100-500
Glucose: <50%

Acute Bacterial Meningitis

9

CSF FINDINGS in Meningitis:

Pressure: 80-150 mmHg
WBC: >1,000
CHON: 50-200
Glucose: usually normal; may be low

Viral Meningitis

10

CSF FINDINGS in Meningitis:

Pressure: elevated
WBC: 10-500
CHON: 100-3,000
Glucose: <50

TB Meningitis

11

CSF FINDINGS in Meningitis:

Pressure: elevated
WBC: 5-500
CHON: 25-500
Glucose: <50

Fungal Meningitis

12

High grade fever, malaise, myalgia, cough, abdominal pain, hepatosplenomegaly, anorexia, diarrhea/constipation

Rose spots

Caused by S. Typhi

Enteric fever

13

Most commonly involved extraintestinal sites for complications of enteric fever

Cns and hepatobiliary

14

Mainstay of diagnosis of Enteric Fever

Blood culture, positive

15

Treatment for Uncomplicated Typhoid Fever

Fully sensitive: Chloramphenicol (14-21days) or Amoxicillin (14days)

Multidrug-resistant: Fluoroquinolone (5-7 days) or Cefixime (7-14 days)

Quinolone resistant: azithromycin (7days) or Ceftriaxone (10-14days)

16

Treatment for Severe Typhoid Fever

Fully sensitive: Azithromycin (14days) or Ceftriaxone (10-14 days)

Multidrug-resistant: Fluoroquinolone (10-14days)

Quinolone resistant: Ceftriaxone (10-14days)

17

Organism crosses the colonic epithelium through M Cells overlying the peyer patches

Shigella

18

Painful defecation, severe abdominal pain, high fever with significant dehydration

Watery voluminous diarrhea initially then into frequent small volume bloody mucoid stools

Shigellosis

19

Most common extraintestinal manifestation of Shigellosis

Neurologic manifestation

20

Definitive diagnosis of Shigellosis

Culture of stool and rectal swab

21

Infantile explosive diarrhea with dehydration

>1y/o; Common in travellers

Responds to TMP-SMX

ETEC

22

Prolonged Nonbloody diarrhea with low grade fever

At risk for are <2y/o especially <6mos

EPEC

23

Shiga-toxin-producing E. Coli

Bloodr diarrhea, afebrile

6mos - 10 y/o; elderly

EHEC

24

Prolonged watery diarrhea that causes significant dehydration

<1y/o; Common in travellers

EAEC

25

Acute onset of profuse, painless, watery diarrhea with rice-water consistency and fishy odor

With vomiting; without abdominal cramps or fever

Cholera

26

Treatment for cholera

Fluid and electrolytes
Tetracycline for 3 days (not for <9y/o); Doxycycline single dose

27

Headache, restlessness, irritability followed by stiffness, trismus, sardonic smile, boardlike rigidity

Tetanus

28

Manifests within 3-12days of birth as progressive difficulty in feeding with associated hunger and crying; paralysis or diminished movement, stiffness to the touch, spasms with or without opisthotonus

Neonatal Tetanus

29

Treatment for Tetanus

Give Tetanus Ig 500 U single dose
Penicillin G (DOC) 100,000 U/kg/day in 4-6hr intervals for 10-14 days

Alternative:
Metronidazole
Erythromycin
Tetracycline

30

Painless papule appears at the site of inoculation 2-6wks after inoculation with regional lymphadenitis

Clean painless ulcer with raised border that heals spontaneously w/in 4-6wks

Primary Syphilis