Infertility Flashcards

(40 cards)

1
Q

a disease characterized by failure to achieve successful pregnancy after 12 months of attempting or due to an impaired capacity to reproduce with one’s partner

A

infertility

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2
Q

in absence of known etiology, and presence of regular, unprotected intercourse, evaluation should be initiated at ____ months when the female is under 35 years old

A

12

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3
Q

in absence of known etiology, and presence of regular, unprotected intercourse, evaluation should be initiated at ____ months when the female is 35 years or older

A

6

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4
Q

what are the 2 most common causes of infertility in couples?

A

tubal/pelvic pathology
male

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5
Q

what is the greatest non-modifiable factor for fertility?

A

female age

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6
Q

maternal age over _____ is associated with placental abruption, pre-term delivery, low birth weight, intrauterine growth restriction, stillbirth, and perinatal mortality

A

40

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7
Q

what are the 3 tests used to evaluate ovulatory function?

A

ovulation predictor kits
basal body temp
mid-luteal serum progesterone level

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8
Q

tests for LH rise in urine to evaluate ovulatory function

A

ovulation predictor kits

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9
Q

what causes the change in body temperature during ovulation?

A

progesterone rise

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10
Q

what is the most common etiology of infertilify?

A

PCOS

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11
Q

what is the criteria for PCOS?

A

2/3:

< 9 menses/year
OR
> 35 day cycle intervals

+

Polycystic appearing ovaries on US

Hyperandrogenism

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12
Q

assesses reproductive potential as a function of the number of oocytes

A

ovarian reserve

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13
Q

what is the most predictive of live birth rates?

A

female age

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14
Q

what are the 3 tests used for ovarian reserve?

A

AMG
FSH/estradiol levels on day 3
antral follicle count

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15
Q

what are 3 tests to assess fallopian tube patency?

A

hysterosalpingogram (HSG)
hysterosallpingo-contrast sonogram
laparoscopy with chromopertubation

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16
Q

at what point in the cycle should a hysterosalpingogram be done?

A

follicular phase (days 5-12)

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17
Q

when should prophylactic antibiotics be considered for a hysterosalpingogram? (2)

A

history of STI/PID
known tubal abnormality

18
Q

what are 2 contraindications for a hysterosalpingogram?

A

pregnancy
purulent cervical discharge
allergy to iodine contrast

19
Q

large fibroids > 4-5cm and those that are close to or inside the endometrial cavity are most concerning

A

uterine leiomyoma

20
Q

patient presents with abnormal bleeding, menorrhagia, and pelvic pressure/pain. Dx?

A

uterine leiomyoma

21
Q

intrauterine adhesions that present with light/absent menses

A

asherman’s syndrome

22
Q

used to evaluate myometrial defects, intracavity defects like polyps, ovarian cysts, antral follicle count, follicular development, and pathology.

A

pelvic sonogram

23
Q

what are the 2 peritoneal factors that cause infertility?

A

endometriosis
pelvic/adnexal adhesions

24
Q

what should be considered to diagnose and treat peritoneal factors leading to infertility?

25
absence of spermatozoa in semen
azoospermia
26
deficiency of spermatozoa in semen
oligospermia
27
poor semen motility (weak)
asthenospermia
28
morphologic abnormality of sperm
teratospermia
29
what should be encouraged during pre-conception counseling? (2)
prenatal vitamins folic acid 1mg
30
what is the optimal timing of intercourse? (2)
1-5 days prior to ovulation intercourse every day to every 3rd day
31
what are 3 vaginal lubricants that are not spermicidal?
canola oil mineral oil hydroxyethyl-cellulose-based lube
32
what is the 1st line treatment for infertility?
lifestyle modifications
33
what are 2 second line treatment options for infertility? (2)
letrozole clomiphene citrate
34
what is the ovulation induction protocol?
letrozole 2.5mg on cycle day 3
35
what is the ovulation induction protocol if a patient is amenorrheic? (2)
induce menses with Provera 10mg x 10 days random start of letrozole 2.5 mg
36
what is the ovulation induction protocol if a patient is nonresponsive?
increase dose to letrozole 5mg x 5 days
37
used in patients with PCOS for anovulation
metformin
38
what is the optimal treatment for unexplained infertility?
clomiphene citrate + intrauterine insemination for 3-6 attempts
39
most aggressive treatment for infertility but has the highest success rate
in vitro fertilization
40
what are 4 benefits of IVF?
decrease # of necessary sperm fallopian tubes not needed control # of embryos transferred preimplantation genetic testing