Inflammation 1 Flashcards
(29 cards)
Define inflammation
The (complex) reaction of living, vascularized tissue to local injury
What does inflammation do?
It is a beneficial, non-specific (innate) response that brings cells and molecules of host defense from the circulation to the site of injury
How do we denote inflammation?
with the suffix -itis
Is inflammation always on?
No, it must be turned off to allow healing to occur (anti-inflammatory response)
What makes inflammation a protective or defensive response?
It removes pathogens
It clears necrotic debris
It aids in tissue remodeling (healing)
What are the components of inflammation?
Cells, noncellular components, blood vessels, and leukocytes (might be more idk)
What kind of tissue does inflammation occur in?
ONLY living tissue
What part of the stomach to we typically see rupture?
Greater curvature
If a wound doesn’t heal what happens?
Inflammation continues going
acute –> sub-acute –> chronic
Will inflammation start spontaneously?
No, it’s a response to an initiating event
What does double edged sword mean when it comes to inflammation?
Inflammation is a healing process and is protective but it can be harmful if it is on too much or for too long
What are four disorders that can be caused by excess inflammation?
Cirrhosis, atherosclerosis, proud flesh, and bronchopneumonia
What type of reaction is inflammation fundamentally?
Defensive
Where are many of the components of inflammation located?
In the blood
Why is plasma an important component of the inflammatory response?
It has clotting factors that are important for coagulation and fibrin
Where around or in the cell does inflammation take place?
It’s a surface phenomenon due to cell receptors
Define acute inflammation
The initial and rapid response to an inciting stimulus (ex: bug bite) (few hours to days of infection)
When does chronic inflammation occur?
When acute inflammation fails to clear the stimulus (weeks to months of an infection)
What cells are involved in acute inflammation?
Neutrophils
What cells are involved in chronic inflammation?
Mononuclear cells (macrophages, lymphocytes, and plasma cells)
Does fibrosis occur in acute and/or chronic inflammation?
Does not occur in acute, but does in chronic
What are four causes of inflammation?
Infectious agents, tissue necrosis, foreign bodies, and immune reactions
Define ischemia
Infarction; occluding a blood vessel
What are a few systemic effects of inflammation?
Leukocytosis (high WBC)
fever
sepsis - when toxic bacterial products are circulating in the blood (endotoxemia, LPS)
