Inflammation Flashcards
1
Q
vasoactive amines
A
histamine and serotonin
2
Q
histamine
A
Mast cells (in response to IgE, C3a, C5a, etc.)
– Vasodilation, increased vascular permeability,
bronchial constriction, pain/itching, tachycardia, and
eosinophil chemotaxis
3
Q
serotonin
A
Platelets
– Similar actions to those of histamine
4
Q
Plasma proteins and proteases
A
Kinin system, complement system, clotting and fibrinolytic systems
5
Q
arachidonic acid
A
COX pathway and Lipoxygenase pathway
6
Q
Cytokines: IL-1 and TNFalpha
A
major cytokines of acute inflammation.
from activated macrophages, NK cells, Endothelial cells
7
Q
Nitric oxide
A
Short acting soluble free-radical gas with functions.
produced by endothelial cells and macrophages
8
Q
O2 derived free radicals
A
produced and released by macrophages and neutrophils (to kill microbes.
