Inflammation and tissue repair Flashcards Preview

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Flashcards in Inflammation and tissue repair Deck (34)
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1
Q

minor damage (often with overuse)

A

microtrauma

2
Q

significant destructions (often with acute trauma)

A

macrotrauma

3
Q

4 causes of tissue damage:

A
  • direct trauma
  • surgery
  • pathology and disease processes
  • problematic healing and/or presence of infection
4
Q

A non-specific immune response that occurs in reaction to any type of bodily injury regardless of cause; stereotyped response that is identical and predictable regardless of causative factor

A

inflammation

5
Q

inflammation of rapid onset and rapid resolution. The majority of the response is usually over within 12-24 hours

A

Acute inflammation

6
Q

inflammation that is less intense but sustained over a prolonged period of time. It may be characterized by chronically elevated WBC count, low grade fever and pain

A

chronic

7
Q

inflammation that can last for months to years, is pathological, delays healing

A

chronic

8
Q

a local or generalized condition in which the body tissues contain an excessive amount of fluid (interstitial tissue)

A

edema

9
Q

the presence of a microorganism that produces tissue damage.

A

infection

10
Q

Signs and symptoms of this are similar to that of inflammation, so be aware of any acute changes in symptoms such as:

  • low grade fever
  • pus/drainage with foul odor
  • flu-like symptoms
A

infection

11
Q

The 4 cardinal signs of inflammation:

A
  • heat
  • erythema (redness or rubor)
  • swelling
  • pain
12
Q

____ may be seen with extensive inflammation or in the presence of infection

A

fever

13
Q

timeframes are ______ and will not be the same for all patients and/or injuries

A

general

14
Q

3 stages of tissue repair:

A
  1. inflammatory response phase (0-4 days, peaking 24-72 hours post injury)
  2. proliferation phase (fibro-blastic repair, day 2 to 6 weeks)
  3. maturation (remodeling) phase (3 weeks to 2 years)
15
Q

_____: one year post injury- 50-70% of normal tensile strength

A

ligament

16
Q

_____ can take 6 months to heal

A

muscle

17
Q

_____ can take year to years to heal

A

bone

18
Q

Stage S&S:

  • cardinal signs of inflammation are present
  • pain to touch with muscle guarding
  • pain with motion
  • decreased strength
A

Stage 1: inflammation phase

19
Q

Stage 1 inflammation phase 4 actions:

A
  • vasoconstriction
  • vasodilation
  • clot formation
  • phagocytosis
20
Q

3 treatment principles of inflammation phase:

A
  1. Control the formation of excess inflammation
  2. Control pain
  3. (P)RICE
21
Q

PRICE

A
P - protection
R - rest
I - ice
C - compression
E - elevation
22
Q

Stage S&S:

  • swelling persists
  • cardinal signs are resolving (post 72 hr window)
  • pain to touch and pain with motion
A

Stage 2: proliferation phase

23
Q

Stage 2:

  • growth of endothelial capillary buds into the wound is stimulated by lack of oxygen
  • the wound becomes capable of healing aerobically
  • increased oxygen delivery
  • increased blood flow
A

revascularization

24
Q

Stage 2:

  • formation of granulation tissue
  • granular mass of connective tissue that fills in the gaps during the healing process
  • capillaries grow
  • fibroblasts arrange parallel to them
  • fibroblastic cells synthesize an extracellular matrix
  • fibroblasts produce collegen fibers
A

formation of scar

25
Q

Treatment goals of the proliferation phase:

A
  1. Facilitate healing by increasing:
    - enzyme activity
    - circulation
    - oxygenation
  2. Prevent re-injury
26
Q

Stage S&S:

  • mild swelling, but should be resolving
  • all symptoms should continue to be resolving
  • ROM and strength will gradually become comparable to unaffected side
  • patient should be returning to functional activities
A

Stage 3 maturation phase

27
Q

As long as the scar appears redder than surrounding tissue, ____ ____ is still occurring

A

scar remodeling

28
Q

Usually by the end of week #, the scar is firm, strong, and nonvascular

A

3

29
Q

during maturation phase ____ is in continual synthesis and break down

A

collagen

30
Q

scar tissue orientation based on stresses placed on it

A

Stage 3 Maturation phase:

Collagen fiber orientation

31
Q

Treatment goals of the maturation phase

A
  1. increase: ROM, strength, scar mobility

2. Return patient to prior level of function

32
Q

4 Outcomes of tissue healing:

A
  1. normal, full healing of like tissue
  2. scar tissue formation
  3. impaired healing/abscess formation
  4. chronic inflammation/non-healing
33
Q

Pharmacological management for inflammation involves (3):

A
  • NSAIDS (Ibuprofen, Naproxen, celebrex)
  • Steroid medications (cortisone, prednisone, dexamethasone)
  • Aspirin
34
Q

4 physical agents/interventions for treatment of inflammation:

A
  • PRICE (initially)
  • E-stim, Ionto, non-thermal US, cryotherapy (initially)
  • Manual techniques
  • Therapeutic exercise/activities