Inflammation I

Question 1

radiation therapy

Answer 1

apoptosis of tumor

-free rad damage and dsDNA breaks

Question 2

intrinsic apoptosis

Answer 2

cytochrome c from mito

Question 3

Bcl2 function

Answer 3

prevent cytochrome c - inhibit apoptosis

binds and inhibits Apaf-1

Question 4

follicular lymphoma

Answer 4

overexpression Bcl2 - no apoptosis

Question 5

karyorrhexis

Answer 5

fragmentation

Question 6

pyknosis

Answer 6

shrink

Question 7

extrinsic apoptosis

Answer 7

Fas-FasL

-Fas coalesce - form FADD - activate caspases

Question 8

CD95

Answer 8

Fas

Question 9

coag necrosis

Answer 9

cell outline preserved

Question 10

caseous necrosis

Answer 10

TB and fungi

Question 11

fat necrosis

Answer 11

trauma breast

acute pancreatitis

Question 12

wet gangrene

Answer 12

superinfection - liquefactive

Question 13

irreversible cell injury

Answer 13

mito vacuoles
lysosome rupture
membrane damage

Question 14

heart susceptible hypoxia

Answer 14

subendocardium

Question 15

kidney susceptible hypoxia

Answer 15

straight segment prox tube
thick ascending limb

in medulla

Question 16

liver susceptible hypoxia

Answer 16

zone III - around central vein

Question 17

watershed areas colon

Answer 17

splenic flexure

rectum

Question 18

hypoxic ischemic encephalopathy

Answer 18

affect pyramidal cells hippocampus

purkinje cells of cerebellum

Question 19

dolor

Answer 19

pain - due to bradykinin

Question 20

histamine

Answer 20

dilate arteriole

increased venule permeability

Question 21

acute inflammation

Answer 21

neutro, esino, antibody

Question 22

chronic inflammation

Answer 22

mononuclear cells

Question 23

chromatolysis

Answer 23

neuronal cell body after axon injury

increased protein synthesis to repair axon

cell swells
displace nucleus periphery
disperse nissl substance throughout cytoplasm

Question 24

dystrophic calcification

Answer 24

injured tissue - 2ndary to necrosis

normocalcemia

Question 25

metastatic calcification

Answer 25

with hyperCa high pH favor deposition

Question 26

extravasation of leuocyte location

Answer 26

post cap venules

Question 27

extravasation of leukocytes

Answer 27

1 - margination and rolling 2 - tight binding 3 - diapedesis 4 - migration

Question 28

margination and rolling

Answer 28

selectins bind sialyl lewis glyCAM1, CD34 - binding L-selectin defective - leukocyte adhesion deficiency type 2

Question 29

tight binding

Answer 29

ICAM1 (CD54) bind DC11/18 integrin VCAM1 (CD106) bind VLA-4 integrin CAM > integrin defective - leukocyte adhesion deficiency type 1

Question 30

diapedesis

Answer 30

PECAM-1 bind PECAM-1 CD31-CD31 travel between endo cells

Question 31

migration

Answer 31

``` chemotactic products -C5a IL-8 LTB4 kallikrien PAF ```

Question 32

free rad damage

Answer 32

lipid peroxidation protein modificaion DNA breaks ``` with acetaminophen OD hemochromatosis reperfusion injury CCL4 - fatty liver change retinopathy of prematurity ```

Question 33

CCl4

Answer 33

cause fatty liver change | -free rad damage

Question 34

scar formation

Answer 34

70-80% strength after 3 months

Question 35

hypertrophic scar

Answer 35

collagen parallel confined to original wound

Question 36

keloid scar

Answer 36

disorganized collagen beyond border of wound more in AAs

Question 37

PDGF

Answer 37

collagen synthesis from platelets and macros vasc remodeling and SMC migration (atherosclerosis)

Question 38

FGF

Answer 38

stimulate angiogenesis

Question 39

VEGF

Answer 39

stimulate angiogenesis

Question 40

TGF-B

Answer 40

angiogenesis, fibrosis, cell cycle arrest

Question 41

EGF

Answer 41

stimulate cell growth - tyrosine kinases