Flashcards in Inflammatory Disorders of the Stomach Deck (24)
gastritis can either be ___ or ___
acute or chronic
in acute gastritis - They have either_____ something or have ____ injury (alcohol, NSAIDS) or systemic problems have put stress on the stomach. The stomach responds to ___ sensitively with inflammation
They have either ingested something or have chemical injury (alcohol, NSAIDS) or systemic problems have put stress on the stomach. The stomach responds to stress sensitively with inflammation
what are the causes of chronic gastritis? 3
______ is the rarest cause of chronic gastritis
what are the characteristics of autoimmune and what is it referred to as clinically?
Vitamin B12, macrocytic anaemia and a form of gastritis
autoimmune is associated with circulating antibodies to ___ ___ cells and is an example of ___ ___ autoimmunity
gastric parietal, organ specific
what are the antibodies in autoimmune chronic gastritis?
anti-parietal and anti-intrinsic factor
what happens to the stomach pathologically in autoimmune chronic gastritis
You get atrophy and intestinal metaplasia in the body of the stomach
with autoimmune chronic gastritis there is an increased risk of ____
what causes anaemia in autoimmune gastritis?
The loss of parietal cells and intrinsic factor deficiency causes anaemia
what is the most common cause of chronic gastritis?
The bacteria - H.P- do not invade the body - they just sit within the body cavity and inhabit a niche between the _____ __ surface and ___ ____
The bacteria do not invade the body - they just sit within the body cavity and inhabit a niche between the epithlial cell surface and mucous barrier
what do the bacteria look like histologically?
gram negative curvillinear rod
H P It excites an early acute inflammatory reaction leading to _____ infiltration. If this is not cleared then you get chronic active inflammation
which interleukin is critical in H P gastritis?
the gastritis and damage from HP is what leads to the gastritis we see in____
what does H P gastritis increase the risk of?
- duodenal ulcer
- gastric ulcer
- gastric carcinoma and lymphoma
what happens histologically to the cell in HP gastritis
Diffuse thickened antral type mucosa (antral gastritis means more prone to duodenal ulcer)
in HP gastritis you get tonnes of inflammatory cells in the ___ ___
what causes chemical gastritis , examples 3
NSAIDS, alcohol, bile reflux
what feature of these chemicals allow them to have a potent attack mechanism?
they are fat soluble
in which patients is bile reflux a common cause of gastric epithelial cell injury?
patients with gastroduodenal motility disorders which may be a primary phenomenon or may follow surgery to the pyloric region
what happens histologically in chemical gastritis?
Get marked epithelial regeneration, hyperplasia, congestion and little inflammation