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Flashcards in Inflammatory Disorders of the Stomach Deck (24)
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1

gastritis can either be ___ or ___

acute or chronic

2

in acute gastritis - They have either_____ something or have ____ injury (alcohol, NSAIDS) or systemic problems have put stress on the stomach. The stomach responds to ___ sensitively with inflammation

They have either ingested something or have chemical injury (alcohol, NSAIDS) or systemic problems have put stress on the stomach. The stomach responds to stress sensitively with inflammation

3

what are the causes of chronic gastritis? 3

abc
autoimmune
bacterial
chemical

4

______ is the rarest cause of chronic gastritis

autoimmune

5

what are the characteristics of autoimmune and what is it referred to as clinically?

Vitamin B12, macrocytic anaemia and a form of gastritis

penriscious anaemia

6

autoimmune is associated with circulating antibodies to ___ ___ cells and is an example of ___ ___ autoimmunity

gastric parietal, organ specific

7

what are the antibodies in autoimmune chronic gastritis?

anti-parietal and anti-intrinsic factor

8

what happens to the stomach pathologically in autoimmune chronic gastritis

You get atrophy and intestinal metaplasia in the body of the stomach

9

with autoimmune chronic gastritis there is an increased risk of ____

malignancy

10

what causes anaemia in autoimmune gastritis?

The loss of parietal cells and intrinsic factor deficiency causes anaemia

11

what is the most common cause of chronic gastritis?

H.Pylori

12

The bacteria - H.P- do not invade the body - they just sit within the body cavity and inhabit a niche between the _____ __ surface and ___ ____

The bacteria do not invade the body - they just sit within the body cavity and inhabit a niche between the epithlial cell surface and mucous barrier

13

what do the bacteria look like histologically?

gram negative curvillinear rod

14

H P It excites an early acute inflammatory reaction leading to _____ infiltration. If this is not cleared then you get chronic active inflammation

neutrophil

15

which interleukin is critical in H P gastritis?

IL8

16

the gastritis and damage from HP is what leads to the gastritis we see in____

PUD

17

what does H P gastritis increase the risk of?

- duodenal ulcer
- gastric ulcer
- gastric carcinoma and lymphoma

18

what happens histologically to the cell in HP gastritis

Diffuse thickened antral type mucosa (antral gastritis means more prone to duodenal ulcer)

19

in HP gastritis you get tonnes of inflammatory cells in the ___ ___

lamina propria

20

what causes chemical gastritis , examples 3

NSAIDS, alcohol, bile reflux

21

what feature of these chemicals allow them to have a potent attack mechanism?

they are fat soluble

22

in which patients is bile reflux a common cause of gastric epithelial cell injury?

patients with gastroduodenal motility disorders which may be a primary phenomenon or may follow surgery to the pyloric region

23

what happens histologically in chemical gastritis?

Get marked epithelial regeneration, hyperplasia, congestion and little inflammation

24

chemical gastritis can cause ____ or ____

ulcers or erosions