Inflammatory Joint Disease

Question 1

Immune mediated polyarthritis is usually idiopathic, non-erosive and may be genetic. What do breed is it mostly found in?

Answer 1

Novia Scotia Duck Trolling Retriever

Question 2

What is the pathophys of immune mediated polyarthritis?

Answer 2

o abnormal B-cell/T-cell reaction with synovial membrane antigens
o Type 1 is idiopathic and is the most common type
o Can be caused by distant infection or drug-induced (ex Doberman with drug induced IMPA to sulfa drugs)

Question 3

CS of Immune mediated polyarthritis:

Answer 3

Multiple joint pain or swelling– generalized stiffness- shifting leg lameness- pyrexia!!! FEVER

Question 4

Diagnostic approaches to Immune mediated polyarthritis:

Answer 4

o Arthrocentesis
o Rads- effusion and swelling will be seen, no erosion or bone proliferation
o Hematology, urinalysis
o Synovial fluid – make sure you do AEROBIC and ANAEROBIC cultures—will usually be negative!!!
o Serology
((Overall…. START with rads and bloodwork… and then maybe culture and serology ))

Question 5

Treatment of Immune mediated polyarthritis:

Answer 5

Abx, immunosuppressive drugs and steroids to put the dog in remission, surgery is uncommon and last ditch effort (Arthrodesis)

Question 6

Erosive Immune mediated polyarthritis - what is the most impt test?

Answer 6

RADS

Question 7

Erosive Immune mediated polyarthritis- prognosis

Answer 7

poor prognosis

Question 8

Tx of patient with Erosive Immune mediated polyarthritis

Answer 8

immunosuppressive drugs as before, gold therapy drugs may be indicated, limited success with arthrodesis because only targets pain, not overall/underlying issue

Question 9

You see a rad with intracapsular swelling, collapsed jt spaces, subchondral bone erosion and periarticular osteophytosis, what do you suspect?

Answer 9

Erosive Immune mediated polyarthritis

Question 10

____ progressive polyarthritis and _____ polyarthritis are immune mediated diseases

Answer 10

Feline progressive polyarthritis, greyhound polyarthritis

Question 11

What is similar to rheumatoid arthritis in dogs?

Answer 11

greyhound polyarthritis

Question 12

T/F, female cats are most affected to feline polyarthritis and has to be positive forFeLv

Answer 12

False; it is male cats ONLYYY; Doesn’t have to be positive for FeLV, only 66% of them are- its a viral contributor it seems

Question 13

Characteristics for Erosive polyarthritis in Greyhounds:

Answer 13

• Idiopathic immune mediated polyarthritis, usually symmetrical
• Most common in metacarpophalangeal joints—even in greyhounds that never raced
• Treat with immunosuppressive drugs

Question 14

Infectious jt disease aka ? is less common than immune mediated arthritis

Answer 14

septic arthritis

Question 15

what is the most common form of infectious jt disease aka septic arthritis?

Answer 15

Bacterial arthritis (STAPH MOSTLY) next is strep 
Cats will see Pasteurella and Bacteroides

Question 16

Abx protocol for septic joint–>

Answer 16

Need a broad spectrum antibiotics until culture comes back, pain meds, treat MINIMUM OF 4-6 WEEKS, EXTEND AT LEAST 2 WEEKS BEYOND RESOLUTION OF ALL CLINICAL SIGNS to prevent relapse