Influenza Flashcards
1
Q
Type of virus?
A
RNA virus - mutates quicker than DNA virus
8 segment genome - orthomyxoviridae family
2
Q
3 groups?
A
IfA - mammals, birds
IfB + IfC - affects humans
3
Q
surface proteins - classifications
A
H - haemagglutinin: viral attachment (18 types)
N - neuraminidase: new virion release (11 types)
4
Q
antigenic drift?
A
continous point mutations of Ag properties. mutations decrease Ab recognition + binding
5
Q
antigenic shift?
A
abrupt - re-assortment in gene segments. new combination of 2 or more strains: new H/N combo. able to jump species.. 25% pop affected –> pandemic
6
Q
virus shedding
A
how contagious you are - 1st 4 days
7
Q
PC
A
- incubation 2-4 days
- abrupt fever for 3 days
+/- myalgia, rhinorrhea, headache, cough, sore throat, malaise
SYSTEMIC
8
Q
HIGH RISK GROUPS?
A
PREGNANCY
ANY DISEASE
MORBIDLY OBESE
ELDERLY
9
Q
TESTS
A
viral nose + throat swab PCR CXR blood culture FBC pulse oximetry U+Es
10
Q
tx for complicated influenza
A
within 48hrs
oseltamivir (tamiflu)
(not in preg)
