Insulin physiology Flashcards Preview

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Flashcards in Insulin physiology Deck (11)
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1
Q

Does insulin cross placenta?

A

No

2
Q

Preproinsulin synthesized where?

A

RER

2
Q

Name the glucose transporter:

adipose, striated muscle

Insulin dependent?

A

GLUT-4

Yes

2
Q

Describe the intracellular mechanism by which glucose entry into beta cell stimulates insulin release

A

Glucose enters through GLUT-4

Glycolysis generates ATP

ATP-sensitive K channel closes

Membrane depolarizes and Ca enters scell

Increase in intracellular Ca stimulates insulin exocytosis

4
Q

Insulin receptor is what kind of receptor

A

tyrosine kinase

5
Q

Name the glucose transporter:

spermatocytes, GI tract

Insulin dependent?

A

GLUT-5

No

6
Q

Name the glucose transporter:

beta islet cells, liver, kidney, intestine

Insulin dependent?

A

GLUT-2

No

7
Q

Name the glucose transporter:

RBC, brain, cornea

Insulin dependent?

A

GLUT 1

No

9
Q

Pt workup demonstrates elevated insulin and elevated C peptide: organic or factitious?

A

organic

10
Q

Name the glucose transporter:

brain

Insulin dependent?

A

GLUT-3

No

11
Q

Effect of growth hormone on insulin release

A

Increases it