Integration 3: Metabolic Switching: Fasting, Caloric Restriction and Keto Diets Flashcards
What are different fasting eating patterns?
- caloric restriction
- intermittent fasting
- alternate-day-fasting
- alternate day modified fasting
- time restricted feeding
- periodic fasting
What is metabolic switching?
preferential shift from utilization of glucose to fatty-acid mobilization for FFAs and ketones
When does metabolic switching occur?
third phase of fasting
* glycogen depleted
* 12-36hrs of after cessation of food consumption
WHat is the purpose of metabolic switching?
sustain function of muscle and brain during fasting to preserve muscle mass
* ketones preferred
metabolic adaptations of increased ketones
- circulating FFA, AA, glucose and insulin maintained at low concentration
- resilience
- metabolic homeostasis
- tissue repair
- organismal function
ketogenic diet
metabolic switching via modified macronutrient intake
* high fat ~80%
* moderate protein 1g/kg body weight
* low CHO 40-60g/d GI<50
When is ketosis acheived?
blood ketones >0.5 mmol/L
What might KD improve?
- CVD risk factors
- T2D management
- weight loss
- increased HDL
- decreased TG
- changes in LDL particle size
KD and appetite
- reduced appetite (PRO=satiety)
- changes in appetite control hormones = suppress
- metabolic rate increase with gluconeogenesis
potential side effects of KD
- dehydration
- lethargy
- kidney damage
- constipation
- micronutrient deficiences
- social isolation
- bad breath
What might VLCKD be beneficial for?
overweight and obesity management NOT for the general public
