Integration of Metabolism Flashcards
The relationship between insulin and glucagon is ______.
List the phases of starvation in order
Glycogenolytic phase, Gluconeogenic phase, Ketogenic phase, Terminal phase
Only the _____ exports glucose. How come other organs can’t export glucose?
- because they lack glucose-6-phosphatase
Liver glycogen is rapidly depleted within __-__ hours.
In the gluconeogenic phase, the _____ still needs glucose.
What are gluconeogenic substrates?
- odd chain fatty acids
- glycerol (from TAG mobilization)
- amino acids (from protein)
Gluconeogenesis in the liver requires ____.
ATP (producing primarily from FA oxidation)
Why isn’t the gluconeogenic phase sustainable?
Amino acids (from protein) are being degraded too quickly and humans cannot survive loss of 1/3> protein
In the ketogenic phase, the _____ adapts to using ______ ______ as fuel.
- ketone bodies
The rate of __ mobilization reaches its peak during the ketogenic phase. _____ body production in the liver increases.
The ketogenic phase leads to a ______ in glucose consumption and a ______ in the breakdown of ______ ____ from proteins.
- amino acids
What happens in the terminal phase?
- we run out of ketone bodies
- then we start degrading a lot of protein
- pre morbid rise in urea concentration in the urine