interleukins Flashcards
(28 cards)
main sources of IL-1
macrophages
main sources of IL-2
Th1 cells
main sources of IL-3
activated T helper cells
main sources of IL-4
Th2 cells
main sources of IL-5
Th2 cells
main sources of IL-6
macrophages
Th2 cells
main sources of IL-8
macrophages
main sources of IL-10
Th2 cells
main sources of IL-12
dendritic cells
macrophages
B cells
main soures of tumour necrosis factor a (alpha)
macrophages
major sources of interferon y (gamma)
Th1 cells
function of IL-1
acute inflammation
induces fever
function of IL-2
stimulates growth and differentiation of T cell response
function of IL-3
stimulates differentiation and proliferation of myeloid progenitor cells
function of IL-4
stimulates proliferation and differentiation of B cells
function of IL-5
stimulate production of eosinophils
function of IL-6
stimulates differentiation of B cells
induces fever
function of IL-8
neutrophil chemotaxis
function of IL-10
inhibits Th1 cytokine production
also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine
function of IL-12
activates NK cells and stimulates differentiation of naïve T cells into Th1 cells
function of tumour necrosis factor a (alpha)
induces fever
neutrophil chemotaxis
function of interferon y (gamma)
activates macrophages
cytokines produced by macrophages
tumour necrosis factor a IL-1 IL-6 IL-8 IL-12
cytokines produced by Th1 cells
interferon y
IL-2
