Flashcards in Interstitial Lung Disease Deck (31):
What is the interstium?
The Interstitium – space in between two cells
what is the function of the interstitium?
Function of the interstitium are: generating cells, motorway for diffusion, regulates immune function and structural mechanism for collagen i.e. scaffolding.
What happens to the interstitium in interstitial lung disease and how does this effect lung function?
• The development of fibrous tissue in the Interstitium, making lungs less compliant, producing a restrictive Ventilatory defect.
• Airway resistance is NOT increased. In fact, the FEV1/FVC ratio can be > 70%, due to the increased radial traction on the airway, which keeps the airway open.
• Lengthening of the diffusion path between alveolar air and blood impairs gas exchange, with oxygen uptake being affected selectively, as CO2 diffuses much more readily.
What are the histological features of the interstium in ILD?
Histologically there are increase activated Alveolar Macrophages which attract Neutrophils and Eosinophils, local lung damage due to ROS and proteases and tissue destruction and fibrosis.
Why is ventilation and diffusion impaired?
Ventilation is impaired as they become stiff unable to expand and deflate, diffusion is impaired because there is a thick viscous liquid for materials to diffuse between and perfusion as capillaries are destroyed or damaged.
How do patients with interstitial lung disease present?
Shortness of breath, cough (both chronic). On examination (may be asymptomatic) signs of underlying disease, clubbing, cyanosis, tachycardia, signs of right heart failure, tachypnoea, decreased chest movement and course crackles.
What happens to oxygen and carbon dioxide?
Overall decrease in oxygenation and increase in carbon dioxide in the body. Oxygenation is effected first because it is much less soluble.
What is a restrictive deficit?
Interstitial disease creates a restrictive deficit – reduction in how quickly it leaves and the total that is breathed out.
What can be seen on CT scans in interstitial lung disease?
Round cystic areas – honeycombing. Don’t go away when turned over and CT scan taken again. Bottom of lung does most of gas exchange.
What are the different types of interstitial lung disease?
• Occupational – asbestosis, silicosis and coal worker’s pneumoconiosis
• Treatment related – radiation, methotrexate, nitrofurantoin, amiodarone and chemotherapy
• Connective tissue disease – Rheumatoid Arthritis, SLE (systemic lupus erythematosus – systemic autoimmune inflammatory disease), polymyositis (autoimmune disease of the muscle), scleroderma (immune attach o the connective tissues) and sjogren’s (autoimmune disease of the moisture producing glands of the body)
• Immunological – sarcoidosis (formation of granulomas all over the bodies organs) and hypersensitivity pneumonitis (hypersensitivity of alveoli to organic dusts leading to granuloma formation)
• Idiopathic – CFA/IPF (idiopathic pulmonary fibrosis)
What are pigeon fancier's likely to get?
Pigeon fancier very likely to get hypersensitivity pneumonitis
What is IPF?
IPF (idiopathic pulmonary fibrosis). Most common form of idiopathic interstitial disease. Presents at 60-80 years of age, median survival 3 years. Drugs used to treat – pirfenidone and nintedanib – slows decline in FVC but lots of drug toxicity.
How does asbestos effect the lungs? in the EXAM!!!
Asbestos plaques – isolated thickening of the pleura
Diffuse pleural thickening – chronic thickening of the pleura
Benign asbestos pleural effusion (BAPE) – build-up of exudate in the pleural cavity
Asbestosis – interstitial lung disease caused by asbestos
Mesothelioma – cancer of the pleura
Bronchogenic lung cancer – cancer of the epithelium of the bronchus or bronchiole
Rounded atelectasis – rounded and folding of the lungs and the lobes collapse.
What drugs can cause ILD?
Methotrexate (RA and weirdly ILD), bleomycin (lymphoma), amiodarone (arrhythmias) and nitrofurantoin (recurrent UTIs). Treatment is to stop the drug and give steroids.
What is sarcoidosis?
Age of onset 20-80. Often asymptomatic cough or rash. PFT (pulmonary function tests) – normal, restrictive, obstructive and mixed. Biopsy – non-caseating granuloma, differential diagnosis is lymphoma and TB, treatment is none, steroids or methotrexate.
What is pleural fluid circulation, what secreted pleural fluid and where is it absorbed?
Pleural fluid circulation – constant circulation as we produce it then reabsorb it.
Pleural fluid turnover – 15mil per day (but can increase to 300ml)
Produced by capillary filtration (starling’s forces) parietal pleura only.
Absorption – lymphatic drainage, parietal pleural lymphatics – via stomata on parietal surface (mainly on the mediastinal diaphragmatic regions.
How are the parietal and visceral pleura innervated?
Parietal Pleura – somatic sympathetic and parasympathetic innervation by phrenic and intercostal nerves.
Visceral pleura – devoid of somatic innervation. So we only get pain when parietal pleura is inflamed.
How can you get a pleural effusion?
The stomata can be blocked up by infection, elevated systemic venous pressure or other diseases of the lymphatic system such as lymphoma. Can have increase in production of fluid such as in heart failure, liver failure, peritoneal fluid, changes in permeability.
What is a transudate?
Transudate=watery – usually due to decreased oncotic pressure or increased venous pressure.
What is an exudate?
Exudate=proteins – pleural fluid protein divided by serum proteins > 0.5 or the pleural fluid lactate dehydrogenase (LDH) divided by serum LDH is > 0.6.
How do we analyse pleural effusions?
Get fluid sample guided by ultrasound or CT guided. Once we have a sample it is analysed for appearance, cell count, protein, LDH, pH, Glucose and cytology.
Describe the different reasons for the formation of different types of effusions
• Transudate – heart failure, hypoalbuminaemia, atelectasis, nephrotic syndrome, constrictive pericarditis and Meigs syndrome.
• Exudate – infection, TB, Malignancy, Rheumatoid arthritis, pulmonary embolism, asbestos related and pancreatitis.
• Empyema – (pH<7.2, glucose < 3.4mmol) – when the fluid is infected
• Haemothorax – usually traumatic or iatrogenic (due to medical treatment) may need chest drain or surgical drainage
• Chylothorax – milky appearance due to lymphatic interruption, lymphoma or iatrogenic.
What are the common causes of metastatic malignancies in the pleura and what is the most common primary malignancy of the pleura
Metastatic – most common from lung and breast cancer
Primary – mesothelioma form asbestos exposure, Chest pain always present, breathlessness, X-rays: effusion and mediastinal pleural enhancement.
Discuss the epidemiology of pneumothorax
Around 20 cases per 100’000 per year in males but more like 2-6 in females. Common in tall thin males.
Who do primary pneumothraces occur in?
Primary – otherwise healthy people
Who do secondary pneumothraces otherwise occur in?
Underlying lung disease e.g. cancer, COPD etc.
Iatrogenic Pneumothorax – procedures such as due to a clinical line.
What is the common cause of primary spontaneous pneumothraces, how do they present and what is the risk of re-occurrence?
Primary Spontaneous pneumothorax – smoking is important (especially cannabis). Risk of recurrence is 54% within the first 4 years. Present with pleuritic chest pain, dyspnoea (difficult or laboured breathing). Investigations done by CXR (or CT scan if needs be). Small is < 2cm from chest wall and large is > 2cm.
How are pneumothoraces treated?
No treatment for small apart from to return if worsening shortness of breath. Treatment for large via aspiration or chest drain. If recurrent then can glue pleura together – chemical pleurodesis and if this doesn’t work, then can surgically stick the pleura together – open thoracotomy and pleurectomy.
What is a tension pneumothorax?
In tension pneumothorax – pressure of air in pleural cavity is increasing causing cardiovascular compromise (tachycardia, hypotension), shift of apex beat, hypoxaemia and expansion with hyper resonance and absent breath sounds on side of collapse.
Medical emergency – no CXR required – cannula into affected side in the 2nd intercostal space at the sternal angle. Should hear a hisss. Add chest drain and give oxygen.
What precautions must be taken after a pneumothorax?
Can’t fly for at least week after confirmed resolution, permanently no diving allowed unless bilateral surgical pleurectomy.