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Block 7 - GI > Intestine Path > Flashcards

Flashcards in Intestine Path Deck (49)
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1

How can you differentiate the different parts of the small intestine?

duodenum - Brunner's glands
jejunum - lacks Brunner's and Peyer's patches
ileum - Peyer's patches

2

What increases the absorptive surface of the small intestine?

villi, microvilli, and plicae circulares (folds in submucosa)

3

How does the epithelial lining change in the colon and rectum?

shaped into tubular structures called crypts or glands, no villi

4

What do all cells in the large intestine have in common?

proper polarity - nuclei at bottom of cells

5

What is ischemic enterocolitis?

reduction, interruption, obstruction of blood supply
often result of decreased systemic perfusion or anatomic occlusion

6

Where does ischemic injury usually occur within the GI tract?

watershed areas where collateral arteries small and narrow
mostly left colon (splenic flexure)

7

How does ischemic enterocolitis usually resolve?

usually mild and on their own - accessory supply from retroperitoneal portions
minority are gangrenous

8

What are the causes of acute and chronic cases of ischemic enterocolitis?

acute - thrombi/emboli - hemorrhagic due to dual blood supply
chronic - atherosclerosis

9

What are the major variables in ischemic bowel dz?

severity of vascular compromise
period during which it develops
vessels affected

10

What are the two watershed zones?

sup and inf mesenteric arteries
inf mesenteric and hypogastric arteries

11

How does microvascular anatomy affect ischemic bowel dz?

intestinal capillaries run from crypt to surface and hairpin turn before emptying
allows blood to supply crypts (w stem cells) but leaves surface epithelium vulnerable to ischemic injury - look for hyperproliferative crypts w surface atrophy as morphological hallmark

12

What are predisposing conditions for bowel infarcts?

arterial thrombosis
arterial embolism
venous thrombosis
obstruction
non-occlussive ischemia (low flow)

13

What are the three categories of ischemic bowel injury?

mucosal infarct
mural infarction - mucosa and submucosa
transmural infarction - acute occlusion of major mesenteric A

14

What do you see with transmural bowel infarctions?

purple-red hemorrhagic, then blood in lumen and wall edematous and thickened
coagulative necrosis of muscularis propria w/i 1-4 days
possible serositis

15

What are the possible consequences of transmural bowel infarctions?

perf
mucosal barrier breaks down - bacteria enter circulation --> sepsis

16

What do the margins of ischemic damage look like in the bowel?

arterial occlusion - sharply defined
venous occlusion - less distinct

17

What generally causes mucosal and mural infarctions?

hypoperfusion

18

What do you see with mucosal or mural bowel infarcts?

often patchy lesions
hemorrhagic mucosa - maybe ulcers
thickened edematous bowel wall
no serosal hemorrhage or serositis
psuedomembranes may form

19

When are mucosal and mural bowel infarcts completely reversible?

as long as muscularis propria spared and hypoperfusion corrected

20

What is diverticulosis?

blind pouch leading off GI tract - lined by mucosa communicating with gut lumen

21

What is the difference between congenital and acquired diverticulosis?

congenital - have all 3 layers of bowel wall
acquired - lack or have attenuated musc. propria, mostly in sigmoid

22

What are examples of congenital diverticulum?

meckel, normal appendix

23

What are examples of acquired diverticulum?

zenker, colontic

24

What two influences contribute to the genesis of diverticula?

exaggerated peristaltic contractions w elevation of luminal pressure
inherent anatomy of colon - incomplete outer longitudinal muscle gathered into tenia coli and focal defects where neurovascular bundles penetrate

25

Why are diverticula associated with Western diets?

low fiber causes prolonged transit time and increased intraluminal pressure associated w low volume stools

26

What are some symptoms of diverticula?

sensation of inability to empty rectum, alternating constipation and diarrhea

27

What are complications of diverticula?

inflamation or inf
peritonitis, hemorrhage, perf w abscess

28

What other conditions can diverticula resemble?

carcinoma radiologically
appendicitis clinically

29

What types of bowel obstructions are there?

mechanical or functional
majority in small bowel - strangulated (surgical emergency) or not

30

What are the most common causes of bowel obstruction?

mechanical - adhesion, hernia, intussusception, volvulus