Intoxication/ToxicoInfection/Short IP Flashcards Preview

Med Micro Block 4 > Intoxication/ToxicoInfection/Short IP > Flashcards

Flashcards in Intoxication/ToxicoInfection/Short IP Deck (29)
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1
Q

Intoxification

A

Ingestion of preformed toxins, organism does not have to be present

2
Q

Toxico-infections

A

Ingest microorganism with preformed toxin associated released upon replication (part of bug)

3
Q

Infections with short IP

A

toxin acts within 24 hours of entry

4
Q

Staph Aureus Clin

A

Intoxication; sudden onset of severe nausea and vomiting. Rapid onset with IP less than 1-6 hrs

5
Q

Staph Aureus Char

A

Gram pos cocci in clusters

6
Q

Staph Aureus VF

A

Multi enterotoxins which act to stimulate vagus nerve endings in stomach leading to emetic response. Acts as superantigen triggering release of TNF-alpha and IFN-gamma into bloodstream

7
Q

Staph Aureus Trans

A

Contaminated food, high fat such as mayo or custards

8
Q

Staph Aureus Diag

A

Clinical; MSA (spec mannitol ferm) and coag pos, beta-hemolytic

9
Q

Bacillus Cereus Clinical 1

A

Intoxication/emetic syndrome. Ingest preformed cereulide stimulates vagus nerve leading to emetic response. Heat stable. One to six hour IP lasts 24 hours. Profuse vomiting, nausea, abd cramps. Diarrhea absent. Common sources are rice dishes at ambient temps.

10
Q

Bacillus Cereus Clinical 2

A

Infection/Diarrhea Syndrome. Ingestion of organism with subsequent production of enterotoxin which is heat labile. Six to 16 hour IP, lasts 24 hours. Watery diarrhea, nausea, abd cramps, vomiting absent. Source = Stews with veggies, veg dishes

11
Q

Bacillus Cereus Char

A

Gram pos rod, spore forming, aerobe

12
Q

Bacillus Cereus VF

A

Emetic enterotoxin and diarrheal enterotoxin

13
Q

Bacillus Cereus Res

A

Enviroment (rice and veggies)

14
Q

Bacillus Cereus Trans

A

Consumption of toxin/microorganism

15
Q

Bacillus Cereus RF

A

Root vegtables

16
Q

Bacillus Cereus Diag

A

Clinical; stool/vomit/food for toxin or culture

17
Q

Clostridium Perfinges Clin

A

Toxicoinfection. Watery diarrhea with no fever or vomit. Delayed onset (6-24 hrs)

18
Q

Clostridium Perfinges Char

A

Gram pos rod, spore forming, anaerobe

19
Q

Clostridium Perfinges VF

A

CPE is an enterotoxin associated with spore coat. Heat labile that disrupts tight junctions

20
Q

Clostridium Perfinges Res

A

Enviro; gut flora

21
Q

Clostridium Perfinges Trans

A

Contaminated food

22
Q

Clostridium Perfinges RF

A

reheated meats, poultry, gravies (high protein foods)

23
Q

Clostridium Perfinges Diag

A

Detect toxin in feces, culture from food.
Egg yolk agar - lacthinase produces reaction
Double Zone of hemolysis

24
Q

Clostridium Botulinum Clinical 1

A

Botulism in healthy children and adults. Intoxification. 12-72 hr IP, lasts days to months. Bilateral descending paralysis, possible resp impairment. Blurred vision, ptosis, diplopia. Loss of throat and mouth function, dysphagia. Abd pain and constipation

25
Q

Clostridium Botulinum Clinical 2

A

Infant Botulism. Food infection - spores become vegetative cells in gut of infants. Less than 1 yr old due to low normal flora growth. 3-30day IP. Common source = honey, canned foods. Lethargy, constipation, poor sucking = “floppy baby syndrome”

26
Q

Clostridium Botulinum Char

A

Gram pos rod, spore forming, anaerobe

27
Q

Clostridium Botulinum VF

A

Botulism Toxin - blocks ACH, heat labile, on lys phage. 8 different toxins, 4 act on humans. AB toxin, target = cholinergic nerves.

Invasive enzymes: Lipase, caseinase, gelatinase

28
Q

Clostridium Botulinum Diag

A

Toxin assay or Culture

29
Q

Clostridium Botulinum Tx

A

Trivalent botulinum anti-toxin