INTRACERLLULAR COMMUNICATION Flashcards
(39 cards)
can be defined as the communication that
takes place within the cell.
Intracellular communication
The basis for the coordination of the physiological functions within a
multicellular organism is
intercellular signaling
Cells communicate through chemical signals, these chemical signals are
known as
ligands.
also called lipid-soluble ligands, can directly diffuse
through the plasma membrane and interact with internal receptors.
hydrophobic ligands
bind to the
extracellular domain of cell-surface receptors.
Water-soluble ligands
within the target cell must be coordinated, fine-tuned
and channeled within a network of intracellular signaling paths that finally
trigger distinct biochemical reactions and thus determine the specific functions
of a cell
Signal transduction
Tool for Intracellular Signaling (2)
Extracellular messengers
Gap junctions
Cells send out signals in the form of specific
messenger molecules that the target cell transmits into a biochemical
reaction.
Extracellular messengers
are channels that connect
two neighboring cells to allow a direct exchange of metabolites and signaling
molecules between the cells.
Gap junctions
Tool for Intracellular Signaling (2)
Cell–cell interaction via cell-surface proteins
Electrical signaling
A further intercellular communication mechanism relies
on electrical processes.
Electrical signaling
Another form of direct
communication between cells occurs with the help of surface proteins.
Cell–cell interaction via cell-surface proteins
Features of Cell Signaling (4)
Specificity
Amplification
Desensitization
Integration
the complementarity of structure between ligand and receptor binding contributes to the high specificity of the signaling pathway.
Specificity
During intracellular communication, the signal amplifies
several folds to generate the response.
Amplification
Also known as adaption, it is the condition that arises due to the continuous binding of the ligand to the receptor
Desensitization
It can be defined as the ability of the system to receive multiple
signals and produce a unified response appropriate to the needs of the cell.
Integration
Stages of Intracellular
Communication (3)
Reception
Transduction
Response
It refers to receiving
the signal via ligand molecule
binding to the receptor.
Reception
It refers to the
transfer of the signal from the cell surface to the interior of the cell, it is achieved by activating several proteins via phosphorylation,
dephosphorylation.
Transduction
A cell generates a
varying type of response according to the need, which result is the change in the metabolic activity of the cell.
Response
Forms of Cellular
Signaling (4)
Paracrine Signaling
Autocrine Signaling
Endocrine Signaling
Direct Cell Signaling
Signals that act locally
between cells that are close
together
Paracrine Signaling
a type of signaling where the
cell releases a chemical
molecule, which acts as a
ligand that binds to the
receptor on the cell that
produces it
Autocrine Signaling