Intro to Arrhythmias and Anti-arrhythmics Flashcards
_____ Afterdepolarizations: intracellular calcium leads to elevated Na/Ca exchange, resulting in net influx of positive charge (INCX)
Delayed
_____ Afterdepolarizations: reactivation of Ca2+ channels in response to elevated intracellular calcium
Early
_______ is a vagal inhibitor (anti-cholinergic) and an α-adrenergic antagonist
Quinidine
Adenosine ____ funny current.
decreases
Adenosine _____ Ca2+ current.
decreases
Adenosine _____ K+ current.
increases
Autosomal Dominant form of Long QT Syndrome
Romano-Ward Syndrome (RWS)
Autosomal Recessive form of Long QT Syndrome
Jervell-Lange-Nielson Syndrome (JLNS)
Class __ drugs: block beta-adrenergic receptors
II
Class __ drugs: reduce funny current, L-type Ca2+ current, and K+ current
II
Class ___ druges: use-dependent blockers stabilize the inactivated state of Na+ channels, reducing inactivation removal
I
Class ___ drugs: block L-type Ca2+ channels
IV
Class ___ drugs: reduced amplitude of action potential opens fewer K+ channels and slows repolarization
IV
Class ___ drugs: slow Ca2+-dependent upstroke in slow response tissue, which slows conduction velocity
IV
Class ___ drugs: slow upstroke of fast response by blocking Na+ channels
I
Class ____ drugs: block K+ channels
III
Class I__ drugs also prolong refractory period by prolonging Phase 2 via a Class III K+ channel block mechanism
a
Class I__ drugs do not prolong Phase 2 of the action potential.
b
Class I__ drugs prolong Phase 2 of the action potential.
a and c
Class I__ drugs prolong the refractory period.
a, b, and c
Class Ia drugs (3)
Quinidine, Procainamide, Disopyramide
Class Ib drugs (3)
Lidocaine, Mixeletine, Phenytoin
Class Ic drugs (3)
Propafenone, flecainide, encainide
Class II drugs (3)
Propanolol, metaprolol, esmolol
