Intro to Glomerulonephritis Flashcards Preview

Nephrology > Intro to Glomerulonephritis > Flashcards

Flashcards in Intro to Glomerulonephritis Deck (58)
Loading flashcards...
1

What three potential causes of Renal Dz (location wise)?

1. Prerenal
2. Postrenal
3. Renal

2

Where is the glomerulus located?

Cortex

3

Two different causes of most broadly generalized by problems in?

1. Tubular
2. Glomerular

4

This type of cell lines the capillary and provides antithrobotic functions.

Endothelial Cell

5

This type of cell largely controls filtration of solute and protein.

Podocyte (Epithelial Cell)

6

This type of cell can control the capillary loop diameter.

Mesangial Cell

7

This type of cell produced the matriz that supports the capillary loop and has some macrophage-like functions.

Mesangial Cell

8

Two most important aspects of a patient visit to suspect glomerulonephritis?

1. History and Physical
2. Labs

9

Signs of Glomeulonephritis based on Physical Exam?

1. Abdominal Pain
2. Rash
3. Neuropathy
4. Recent Illness
5. Recent Medications

10

Single most important lab in the evaluation of glomerulonephritis

Urine Analysis with Microscopic Exam

11

When the filter of the glomerulus breaks, what will happen?

Loss of Protein and RBCs

12

UA Results of 2+ Protein, 60 RBC would narrow the differential to?

Glomerulonephritis
UTI
RBC from mass lesion in bladder or stone.

13

Two specific finds for glomerulonephritis

1. Dysmorphic RBCs (Acanthocytes)
2. RBC Casts

14

What would you find clinically in nephrOtic Syndrome?

Problem with the glomerulus causing leakage of very large amounts of protein

15

What would you find clinically in nephrItic Syndrome?

Problem with the glomerulus causing leakage of some RBC and less protein

16

Characteristics of Nephrotic Syndrome

1. > 3.5 protinurea/day
2. Hypoalbuminemia
3. Edema
4. Hyperlipidemia
5. Hypercoaguability

*** Not lots of RBSa or RBC casts in urine

17

Characteristics of Nephrutic Syndrome

1. RBCs and RBC Cast in urine
2. Proteinurea (but not massive)
3. HTN
4. Possible renal impairments
5. Possibly more acute

18

Most important diagnostic testing for nephritic syndrome

Renal Biopsy via Renal Consult

19

Primary causes of nephritic syndrome

1. Post-infectious glomerulonephritis
2. IgA Nephropathy
3. Rapidly progressive glomerulonephritis
4. Rapidly progressive glomerulonephritis (Anti-GBM, Idiopathic)

20

Systemic Dz Causes of Nephritic Syndrome

1. Lupus
2. Goodpasture's Dz (Vasculitis)
3. Pauci-Immune Glomerulonephritis's Dz (Vasculitis)
4. Henoch- Schonlein Purpura

21

Most common infection that can lead to post-infectious glomerulonephritis?

Streptococcal (Throat or Skin infection)

***Must be a nephrotoxic strain to cause this

22

After a nephrotoxic strain of strep infection, how soon will you see glomerulonephritis onset?

2-3 weeks

23

Which cause of Nephritic Syndrome is the most common in children 2-14 years old?

Post-Infectious Glomerulonephritis

24

Is post-infectious glomerulonephritis common these days?

Nope, not at all. We are all about antibiotics these days, so this doesn't phase us.

25

Presentation of Post-infectious glomerulonephritis Nephritic Syndrome

1. Tea colored urine
2. Leg Swelling
3. Sore throat that was untreated
4. HTN

26

Lab results of someone with post-infectious glomerulonephritis

1. Protein in urine
2. + Antistreptolysin O
3. Low C3 level
4. Elevated BUN and Creatinine
5. RBCs in urine (low?)

27

Pathogenesis of Post-infectious Glomerulonephritis

Immune complex deposits in the glomerulus

28

Treatment of Post-infectious Glomerulonephritis

1. Supportive (Hugs)
2. Antibiotics (with more hugs)

29

What is the most common type of glomerulonephritis?

IgA Nephropathy!

*Most common in Asia*

30

Presentation of IgA Nephropathy

Usually slow and progressive.
Often asymptomatic
Can present as microscopic or gross hematuria (+mild proteinuria)
Flares during infections