intro to immune system Flashcards
determined by primitive germ line, give 3 examples and its characteristic
innate responses,
examples: monocyte,nk cells,macrophages,dendritic cells,neutro-baso- eosinophils, tissue mast cells
monocytes-carry pathogen receptor recognition cells, first line of defense
3 key properties of highly diverse antigen receptors
highly diverse repertoire of anitgen receptors, immune memory, immunologic tolerance
disadvantage an d advantage of redundancy of immune reactions
advantage: cytokines can be elaborated by different cell lines whch prvide backup
disadvantage: makes specific targeting a challenge
major components of the innate immune system
prrs, complements, antimicrobial peptides,cells of immune system, cytokines
main ligands recognized by toll- like receptors?
bacterial,viral proteins
main PRR (pattern recognition receptors) that recognizes LPS?
leucine rich protein
phosphatidyl cholineis recognize by this PRR. hive example
pentraxin - c reactive protein
enzymes on the complement system
serine proteases
4 pathwaysof complement system
classic activation pathway, mannose- binding lectin activation pathway, alternate activation pathway,terminal
classic,mannose- binding,alternate (cma)
actuvated by binding of c3 directly to pathogens/tumor cells
alternative activation pathway
define opsonization
coating by ab and comple,ents
end result of terminal patheay
membrane attack complex that lyses cells
amplifiers and effectors of innate immune systems
granulocytes
inactivates NK cells to damage to host cells
KIR (killer cell ig-like activating pr inhibitory receptors
presents antigen to cytotoxic t-cell,what activated t - cell is formed after this in response to fungi and virus?
mhc 1(b cell), th1
