Intro to MS

Question 1

_______ disease, typically marked by exacerbations & remissions.

Answer 1

Demyelinating

Question 2

Affects approximately _______ persons in the U.S.

Answer 2

400,000

Question 3

Worldwide approximately ____ million people

Answer 3

2.1 million

Question 4

Rare in ______, onset usually around 50 years of age

Answer 4

children

50 years

Question 5

_____ Women vs men to _____

Answer 5

2:1 women

Men 3:1

Question 6

________ lesions known as Plaques are scattered throughout the CNS white matter

Answer 6

Demyelinating

Question 7

Most common areas involved:

Answer 7

• Optic nerve
• Subcortical white matter-motor cortex
• Corticospinal tracts
• Posterior columns
• Cerebellar peduncles

Question 8

Cerebellar peduncles:

Answer 8

Balance, posture, proprioception and vestibular information

Question 9

Demylinization impairs neural transmission and causes nerves to ______ rapidly

Answer 9

fatigue

Question 10

Local inflammation around the ACUTE lesion further interferes with NERVE conductivity

Answer 10

acute

nerve

Question 11

MYELIN sheaths are eventually replaced by FIBROUS scars _______

Answer 11

Myelin
fibrous
plaques

Question 12

Symptoms vary _____ and the exact ______ of disease is ________

Answer 12

greatly
course
unpredictable

Question 13

As the disease PROGRESSES, remissions become LESS complete and neurological DYSFUNCTION increases.

Answer 13

progresses
less
dysfunction