Intro To Pharmacology Flashcards
1
Q
What do agonists do
A
- Activate post synaptic membrane receptors
- Mimic the action of endogenous
- neurotransmitters
2
Q
What is an adrenergic agonist
A
- sympathomimetic
3
Q
Cholinergic agonist
A
- parasympathetic
4
Q
What is an antagonist
A
- block or occupy post synaptic membrane receptors
- reduce the activity of neurotransmitter
5
Q
Modes of drug administration
A
- oral
- ocular
- nasal
- sublingual
- epidermal
- rectal
- vaginal
- injection
6
Q
Effect of first pass metabolism
A
- reduces proportion of active drug available at the target site
7
Q
Advantages of topical administration
A
- direct
- increased availability
- improve effect
- rapid effect
- significantly reduced risk of ADRs
8
Q
Risk of topical drugs
A
- systemic absorption
- no first pass metabolism
9
Q
Ways to prevent systemic absorption with topical drugs
A
- leave time between drop
- lid closure after instillation, 67% reduction in systemic absorption
- consider viscosity
- consider ocular health
