Introduction Flashcards
What are cells?
Elementary particles of organisms.
What are the key components of cells?
Cytoplasm, nucleus, ribosome, mitochondria, cell membrane.
From who did the origin of the term cell come from?
Robert Hooke (1635-1703).
Who was the first microscopist?
Antoni van Leeuwenhoek (1632-1723).
What is preformationism?
A popular theory that organisms develop from miniature version of themselves.
What was the cell theory and who pioneered it?
Observed similarities between animal and plant - aggregate of fully individualised independent beings - Theodore Schwann and Matthias schleiden.
What were the first two tenets of cell theory 1838?
All living organisms are composed of one or more cells, the cell is the basic unit of structure and organisation in organisms.
What did Hugo Von Mohl do?
First to observe cell division in algae and plant cells.
What did Robert remak do?
First to observe cell division in chicken blood cells and from embryo.
What did rudolf virchow do?
First person to describe leukaemia, accept remak’s cell division, publish extension to theory in 1855.
What were the extensions to cell theory in 1855?
All cells from other cells, normal physiology is function of cellular physiology, disease, disruption of physiology is result of disrupted physiology of cells.
Roughly how many years did it take from first seeing cells to manipulating them?
~300 - first observation 1665, first IVF 1978.
How did cellular pathology arise?
Originally physicians focused on breakdown of visible things, Virchow argued doctors need to look for disruption in organ’s invisible units.
What is SARS-CoV-2?
Spike protein, ACE2 receptor, cytokine storm, systemic inflammatory overdrive.
What is cancer?
Abnormal proliferation division, genome stability, DNA damage, genetics inheritance.
What can cellular pathology lead to?
Antibiotic development, infertility, infectious pathogens, Alzheimer’s, animal plant behaviour, genome dating, plant metabolites, GMO plants.
