Introduction Flashcards
(29 cards)
state tow antigen presenting cells?
macrophages
dendritic cells
what s the life span for neutrophils ?
a few days
what are the function of neutrophils?
phagocytosis
degranulation
what are the main targets of neutrophils ?
bacteria
fungi
what is the life span for eosinophils ?
8-12 days
what are the main functions of eosinophils?
extracellular killing via degranulation
what two interleukins stimulate eosinophils production?
IL-5 and IL-3
what is the main function of basophils?
degranulation
- histamine, prostaglandins, cytokines
what are the main target of basophils?
parasites
how long do mast cells last for?
long life span
what is the main target of mast cells?
parasites
what are the main functions of macrophages?
phagocytosis
antigen presentation to T cells
release of TNF-alpha, IL-2 and IL-6
what are the three tissue based monocytes ?
kupffer, microglial, mesangial
once activated where do the dendritic cells do?
they migrate to the lymphoid tissues
what are the main functions of dendritic cells?
phagocytosis
antigen presenting to CD4 cells
script TNF alpha and interleukins
what are the main function of natural killer cells
Bind to and kill virus-infected and cancerous cells –reduced MHC I expression
what do natural killer cells release from their granules ?
perforin and granzymes
- induce apoptosis
is the adaptive immune repose immediate ?
no - its delayed
state three mucosa associated lymphoid tissue?
GALT - appendix - peyers patches BALT NALT
what cells have MHC1 ?
all nucleated cells
what cells have MHC II?
antigen presenting cells
what does MHC1 bind to ?
binds to CD8 T cells
what does MHC II bind to ?
binds to CD4 T cells
what is the biggest of the human immunoglobulins?
IgM
