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1

A substance that stimulates antibody formation and has the ability to bind to an antibody

Antigens

2

A LMW, non-antigenic substance that, when combined with an antigen, changes the antigenic specificity of that antigen

Hapten

3

A glycoprotein substance that is produced by lymphocytes in response to an antigen

Antibody

4

Derived from a single B-cell clone and are produced as a single class of immunoglobulin with specificity unique to the antigenic stimulus

Monoclonal antibodies

5

Produced as different classes of immunoglobulins by many B-cell clones in response to an antigen

Polyclonal Antibodies

6

The part of an antigen that reacts specifically with an antibody or T-cell receptor

Epitope

7

Clumping of particulate antigens by antibodies specific for the antigen

Agglutination

8

The tendency for combining with the antigen-binding site on an antibody molecule

Affinity

9

The strength of the bond between the antigen and the antibody

Avidity

10

The smallest amount of antigen or antibody that can be detected

Sensitivity

11

The ability of an antibody to bind to an antigen with complementary determinants

Specificity

12

Glycoprotein substances secreted by antigen-stimulated B cell

Immunoglobulin

13

Exist as monomer in serum and as a dimer in body secretions

IgA

14

Serum levels

77-400mg/dl

IgA

15

Serum levels

3-5

IgD

16

Serum levels

17 - 450

IgE

17

Serum levels

591 - 1965

IgG

18

Serum levels

50 - 311

IgM

19

Small fragments which attracts and activate different types of leukocytes. It is activated whenever there is an allergen

Anaphylotoxins

20

3 cluster differentiation

CD68 - MACROPHAGES
CD69 - ACTIVATED LYMPHOCYTES
CD70 - REED STERNBERG CELL

21

Gene Product

HLA-A
HLA-B
HLA-C

Class 1 MHC

22

Gene Products

HLA-DP
HLA-DQ
HLA-DR

Class 2 MHC

23

Gene Products

Complemen
TNF
Heat shock protein

Class 3 MHC

24

Ag specificity of Class 1 MHC

8-10 amino acid

25

Ag specificity Class 2 MHC

13-18 amino acid

26

MHC antigen presentation of Class 1

CD8 T-Cells

27

MHC antigen presentation of Class 2

CD4 T-cells

28

Endogenous

Cellular location of recognition

MHC-1

29

Exogenous

Cellular location of recognition

MHC-2

30

Type 1 hypersensitivity reaction

Urticaria
Hay fever
Bronchial asthma