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Flashcards in Introduction Deck (19)
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1
Q

Storage of fat-soluble vitamins

A

Fat soluble vitamins A, E, D, and K may all be stored.

2
Q

Storage of water-soluble vitamins

A

Water-soluble vitamins are not stored, they are excreted constantly by the kidneys. Thus, you must take in a constant stream of water-soluble vitamins A and the various B vitamins

3
Q

Rate Constant Equation

A
4
Q

Transition state thermodynamics

A
5
Q

Catalysis Thermodynamics

A
6
Q

Why is it better for the enzyme to conform to the transition state rather than to the substrate?

A
7
Q

Lineweaver-Burke Plot

A
8
Q

Inhibitor Flow Chart

A

If the inhibitor does not covalently modify the enzyme, it is then classified as a reversible inhibitor. Because these inhibitors can rapidly bind and dissociate from the enzyme, we can further analyze the rela5onship between inhibitor binding and substrate binding. If I (inhibitor) and S (substrate) cannot bind the enzyme at the same time, this is referred to as competitive inhibiton. The opposite of this case is when I can bind to the enzyme ONLY if S is bound first, which is referred to as uncompetitive inhibiton. In between these extremes, binding of S and I may be independent of one another. This is a special case referred to as noncompetitive inhibiton. In reality, pure noncompetitive inhibi5on is fairly rare, as typically the binding of S and I tend to influence one another. Therefore a mixed patern of inhibiton is seen more commonly.

9
Q

Uses of isoflurophate (a.k.a. diisopropyl fluorophosphate)

A

Used exclusively to treat glaucoma as a topical eye drop

Dangerous due to its irreversible inhibition of acetylcholinesterase.

10
Q

Methotrexate

A
11
Q

Noncompetitive inhibitors are by definition. . .

A

Allosteric

12
Q

Uncompetitive inhibition, the rarest form of inhibition, is usually observed in. . .

A

enzymes that bind two substrates in a particular order, with the inhibitor resembling one of the two substrates.

13
Q

Mixed Inhibition

A
14
Q
A
15
Q

Michaelis-Menten

A
16
Q

Michaelis-Menten Derivation

A
17
Q

Acetylcholinesterase mechanism

A
18
Q

Neuromuscular Junction

A
19
Q

Catalytic Triad in AChE

A