Introduction Flashcards

1
Q

What 4 things does the nervous system do?

A
  • Senses input
  • Processes
  • Reacts
  • Memorises
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2
Q

Why does the nervous system need to process information

A

To decide if the input is important enough to fire action potentials

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3
Q

How does the nervous system ‘react’?

A

By executing a certain behavioural programme

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4
Q

As well as memorise, when must the nervous system be able to do?

A

Adapt to changes in the environment

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5
Q

What are 3 important behaviours of an organism?

A

Mating
Eating
Avoiding predators

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6
Q

What determines how the nervous system is organised?

Example?

A

Mating, eating, predators of the organism

Killer fly - eats drosophila - fast photoreceptors
Drosophila eats things that don’t move - slow photoreceptors

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7
Q

What is the resting potential of the neuron and why?

A

-70mV

Due to the selectivity of the membrane channels

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8
Q

Where is sodium high?

A

Outside the cell

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9
Q

Where is potassium high?

A

Inside the cell

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10
Q

Describe the action potential

A
Voltage gated Na channels open 
Membrane depolarises
Membrane potential reaches a peak
Na channels close 
VG K channels open - potential decreases 

Undershoot - hyperpolarisation

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11
Q

What regulates the firing rate of the action potentials?

How?

A

Hyperpolarisation (undershoot)

Longer the undershoot, the smaller the firing rate

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12
Q

How does the action potential propagate along the axon?

A

As Na moves in through the VG Na channels - Na slightly diffuses away to neighbouring part of the axon

Causes this part of the axon to become slightly depolarised

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13
Q

How is the action potential propagated?

A

Through saltatory conduction:

- Jumping of the electrical impulse to the Nodes of Ranvier (where there is no myelin sheath)

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14
Q

What does the myelin sheath do around a neuron?

A

Increases conductance by improving the ‘leakiness’ of the membrane

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15
Q

Which neurons don’t have a myelin sheath and why?

A

Interneurons and neurons of the retina

They are too short

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16
Q

Is GABA excitatory or inhibitory?

A

Inhibitory

17
Q

Is glutamate excitatory or inhibitory?

A

Excitatory

18
Q

What allows rapid release of neurotransmitter from the presynaptic terminal?

A

Some vesicles containing neurotransmitters are already docked at the membrane

19
Q

What happens when an action potential reaches the presynaptic terminal?

A
  • Depolarisation of the membrane
  • Ca2+ influx through voltage gated channels
  • Triggers a conformational change in SNARE proteins
  • Vesicles fuse with the presynaptic membrane
  • Neurotransmitter release
20
Q

What is an EPSP?

A

Excitatory postsynaptic potential:

  • A TEMPORARY increase in the membrane potential in the post synaptic neuron
21
Q

What can occur if there is enough EPSPs?

A

May change the membrane potential in the postsynaptic membrane high enough and trigger an action potential

22
Q

What 2 ways can an action potential occur in the post synaptic membrane?

A

Spatial summation

Temporal summation

23
Q

What are the 3 types of glutamate receptors?

Are these ionotropic or metabotropic?

A

NDMA
AMPA
Kainate

Ionotropic

24
Q

What ions pass through AMPA receptors and how is this different to NDMA receptors?

A

AMPA: Na in and K out

NDMA: Na and Ca in and K out

25
Q

Which glutamate receptors are important in triggering LTP and LTD?

A

NDMA receptors

26
Q

What is an IPSP?

What neurotransmitter can trigger this?

A

Inhibitory post synaptic potential

Triggered by GABA

27
Q

What receptor is usually present on a postsynaptic membrane, which triggers an EPSP?

Which ion is this channel permeable to?

A

GABAa receptor

Permeable to Cl

28
Q

What happens to the postsynaptic membrane during an IPSP?

What does this result in?

A

In is HYPERpolarised

Making is HARDER for an action potential to occur

29
Q

What determines if an action potential occurs in a postsynaptic neuron?

A

The balance between all the EPSPs and IPSPs