Ion- /K channels

Question 1

What is the structure of an ATP-sensitive K channel?

Answer 1

It is an octamer:
4 x Kir 6.2 = pore forming K channel
4 x SUR = sulfonyl urea receptor
consisting of: ->3 x TMD= transmembrane domain
->2 x NBD= nucleotide binding domain

Question 2

What is the throughput rate?

Answer 2

the rate of production or the rate at which something can be processed.
I =1.6 x 10^8 ion/s

Question 3

On which side of the membrane does the K channel work?

Answer 3

Intracellular

Question 4

List some K channel openers

Answer 4

Diaoxide
Pinacidill
cromahalim
minoxidil

Question 5

List some sulfonyl urea inhibitors.

Answer 5

• Sulfonyl urea inhibits the ATP-sensitive K channel

Question 6

Kir 6.2 + SUR 1 location

Answer 6

Pancreatic B cells

Question 7

Kir 6.2 + SUR 2.A location

Answer 7

myocytes, skeletal muscle.

Question 8

Kir 6.1 + SUR 2.B location

Answer 8

vascular SM

used in hypertension because they decrease the vascular tone

Question 9

Clc-1 location

Answer 9

skeletal muscle

stabilizes resting membrane potential

Question 10

Clc-5 location

Answer 10

Kidney prox. tube

Cl- transport

Question 11

Clc-Ka Clc-Kb location

Answer 11

Kidney TAL

Cl- reabsorption