Serotoninergic neurotransmission

Question 1

Where do the ascending axons for the serotinergic system come from?

Answer 1

The cell bodies in the raphe nuclei

Question 2

What is the initial precursor for the production of Serotonin?

Answer 2

Tryptophan

Question 3

Describe the process of Serotonin synthesis from Tryptophan.

Answer 3

1) Try -> 5- hydroxytryptophan
enzyme: tryptophan hydroxylase

2) 5-hydroxytryptophan -> serotonin( 5-HT )
enzyme: aromatic amino acid decarboxylase

Question 4

Describe the process of Melatonin synthesis from Serotonin

Answer 4

1) 5-HT -> N-Acetyl serotonin
enzyme: 5-HT acetyl-tranferase

2) N-Acetyl serotonin -> Melatonin
enzyme: 5-hydroxyindole-O methyltransferase

Question 5

What is the Km for try in the brain?

Answer 5

30-60 uM

Question 6

How does the amount of melatonin increase?

Answer 6

darkness -> + symp activity -> + B-receptor -> cAMP -> + acetyltransferase -> + melatonin synthesis

Question 7

Inhibitor of the Vesicular transporter of serotonin

Answer 7

Fenfluramine

Question 8

name 3 antidepressive drugs

Answer 8

Inhib of MAO
SERT inhibitors
5-HT1a receptor AGONIST

Question 9

name an antipsychotic drug

Answer 9

5-HT2 receptor inhibitors

LSD is a 5-HT2 agonist

Question 10

Name an antagonist against nausea

Answer 10

5-HT3 receptor antagonist. when 5-HT3 receptor is + it will cause nausea.