IP Calcium ion/ PKC pathway

Question 1

Phospholipase-C (PLC)

Answer 1

Phospholipase-C contains a PH domain (Pleckstrin homology domain).

Interacts with the phosphorylated inositol ring of a phospholipid. Cuts the ring.

Question 2

Acetylcholine

Answer 2

Neurotransmitter

-Acts through muscarinic cholinergic receptors to initiate smooth muscle contraction

Epinephrine- does the contrary.

Question 3

DAG

Answer 3

plasma membrane bound that activates another effector proteins.

Bares DAG-binding C1 domain like protein kinase-C

(Not as important)

Question 4

PKC-Protein Kinase C

Answer 4

important for:
-Cellular growth
-cellular metabolism
-differentiation
-cell death
-immune responses
-muscle contraction

Question 5

IP3 receptor

Answer 5

Tetrameric Ca2+ channel

Ca2+= another second messenger. Tightly controlled as it is stored in the Smooth ER

Question 6

Starfish Diagram

Answer 6

Sperm brings PLC in the egg, producing IP3, and overall allows release of calcium