IS-BB

Question 1

condition when these normal cells would proliferate in an abnormal manner

Answer 1

neoplasia

Question 2

abnormal tissue mass

Answer 2

tumor/neoplasm

Question 3

benign tumors: (4)

Answer 3

adenoma
lipoma
fibroma
hemangioma

Question 4

tumor that develops in the epithelial tissue that covers the organs, glands

Answer 4

adenoma

Question 5

blood vessels that have accumulated in the skin or organs

Answer 5

hemangioma

Question 6

arise from fat cells; most common type of benign tumor

Answer 6

lipoma

Question 7

3 distinct features of malignant tumor

Answer 7

• poorly differentiated cells
• can invade surrounding tissues
• can metastasize

Question 8

cancer that often begin in the skin or the tissues that line internal organs

Answer 8

carcinoma

Question 9

cancer that affects the bone marrow and wbcs

Answer 9

leukemia

Question 10

cancer that originates in the immune system and begins with the lymphocytes

Answer 10

lymphoma

Question 11

cancer that develops in the connective tissue

Answer 11

sarcoma

Question 12

aka the secondary tumor

Answer 12

metastatic tumor

Question 13

4 tumor antigens

Answer 13

tumor specific antigens
tumor associated antigens
carcinofetal antigens
spontaneous tumor antigens

Question 14

these are intracellular proteins or molecules that are specific for tumor cells
+ example

Answer 14

tumor specific antigens

ex: alpha fetoprotein

Question 15

these are intracellular proteins or molecules that can be found in both normal and tumor cells; non specific
+ example

Answer 15

tumor associated antigens

ex: p97 (transferrin GF)

Question 16

antigens which are produced normally during the fetal development and would start to decline at birth; if it is still present in adult, it is malignant
+ example

Answer 16

carcinofetal antigens

ex: CEA/AFP

Question 17

t or f. carcinofetal antigens will elicit humoral or cell mediated response

Answer 17

false. since they were formed during fetal development, our body classify it as self antigens

Question 18

antigens which are produced normally during the fetal development and would start to decline at birth

Answer 18

spontaneous tumor antigens

Question 19

natural immunity

successfully used in cancer immunotherapy

Answer 19

activated macrophages

Question 20

natural immunity

affects the tumor vasculature to kill tumor

Answer 20

tumor necrosis factor

Question 21

natural immunity

antibodies wrap the tumor

Answer 21

direct cytolysis

Question 22

natural immunity

granulated lymphocytes; functions as immunosurveillance

Answer 22

NK cells

Question 23

T cell mediated

this cytokine activates the T cells, B cells, NK cells

Answer 23

IL-1

Question 24

T cell mediated

acute inflammatory cytokine that destroys tumor cells by necrosis/apoptosis

Answer 24

TNFa

Question 25

T cell mediated | this cytokine is produced by the T cells and the NK cells; stimulation of the anti-tumor immune response

Answer 25

interferon gamma

Question 26

T cell mediated | provide an effective anti-tumor immunity by directly lysing the tumor cells

Answer 26

cytolytic t-lymphocytes

Question 27

serves as good tumor markers

Answer 27

antibodies

Question 28

normally present in very minimum amounts; elevated when there is cancer

Answer 28

glycoprotein

Question 29

tumor marker category | cell surface markers

Answer 29

ER/PR

Question 30

tumor marker category | proteins

Answer 30

thryoglobulin | bence jones proteins

Question 31

tumor marker category | oncofetal antigens

Answer 31

CEA | AFP

Question 32

``` tumor marker category carbohydrate antigen (4) ```

Answer 32

CA125 CA15-3 CA72-4 CA19-9

Question 33

tumor marker category | enzymes

Answer 33

PSA | neuron specific enolase

Question 34

tumor marker category | hormones

Answer 34

HCG | calcitonin

Question 35

disease associated with CEA

Answer 35

GIT diseases

Question 36

disease associated with AFP

Answer 36

viral hepatitis cirrhosis ulcerative colitis

Question 37

t or f. beta hcg is normal for males

Answer 37

false. it is only seen in testicular cancer and in other tumors