Isoflurane

Question 0

The constant for the Meyer-Overton equation is __ atmospheres

Answer 0

1.8

Question 1

The lower the MAC necessary for anesthesia, the __ the potency and the __ the oil:gas partition coefficient.

Answer 1

Greater potency

Higher oil:gas partition coefficient

Question 2

The oil:gas partition coefficient for Iso is __

Answer 2

97

Question 3

Again, the higher the Oil-gas partition coefficient, the __ the lipid solubility AND potency

Answer 3

Greater

Question 4

Iso causes immobility to painful stimuli by enhancing __ ion channels and reducing spinal neuron action potentials via __ and ___ receptor mediation.

Answer 4

K+ channels

Glycine and GABAa receptor mediation

Question 5

The effects of general anesthetics are very __ , many different receptors in both brain and spinal cord

Answer 5

Diffuse

Question 6

Receptors involved in the spinal cord include __, 5-hydroxytriptamine, __, NMDA, __, and AMPA

Answer 6

Glycine, 5-hydroxytriptamine, Na+, NMDA, K+, and AMPA

Question 7

Receptors involved in the brain include Kainate, ___, ___, alpha-2, 5ht3, ___

Answer 7

Kainate, GABA, OPIOID, alpha-2, 5ht3, ACETYLCHOLINE

Question 8

CFC’s are colorless, odorless, nonflammable, noncorrosive gases or liquids. CFC stands for __

Answer 8

Chlorine
Fluorine
Carbon

Question 9

If iso were entirely fluorinated it would be a non-___

Answer 9

Immobilizer

Question 10

Racemic mixtures are __/__ mixes of stereoisomers

Answer 10

50/50

Question 11

What is the BLOOD-gas partition coefficient of iso?

Answer 11

1.46

Question 12

What is the vapor pressure of iso?

Answer 12

238

Question 13

Is iso stable in moist soda lime and available generically?

Is it ok to use with a closed circuit?

Answer 13

YES
Yes

Stable in soda lime means it doesn’t make any bad compounds.

Question 14

Does iso need a preservative? Does it produce compound A or carbon monoxide?

Answer 14

No
No
No

Question 15

What is the metabolism rate of iso?

Answer 15

0.2%

Question 16

Iso is the only molecule with the __ atom

Answer 16

Chlorine

Question 17

Sevo is the molecule with ___ fluorines

Answer 17

Seven

Question 18

Des is the molecule with NO chlorines and __ fluorines

Answer 18

Six

Question 19

Does iso produce skeletal muscle relaxation?

Answer 19

Yes

Question 20

MAC is completely ___ of the length of the anesthetic

Answer 20

Independent

Length of anesthesia DOES NOT increase or decrease MAC requirements.

Question 21

What is the MAC for iso for age 36-49?

Answer 21

1.2

Question 22

Dose of iso needed to produce apnea is around __ mac

Answer 22

2

Question 23

Iso causes airway irritation around __ mac

Answer 23

1

Question 24

Can you use an LMA with iso?

Answer 24

Yes

Question 25

How much iso MAC for a deep extubation?

Answer 25

0.85 MAC

Question 26

Iso causes peripheral vaso___ and __ body temps.

Answer 26

Vasodilation | Decreases body temps

Question 27

Does iso alter the hypoxia pulmonary vasoconstriction? HPV

Answer 27

Yes

Question 28

Does iso predispose arrhythmias or protect against them? Would your electrophysiologist want you to use iso?

Answer 28

Protects against them, anti arrhythmic You EP would NOT want you to use iso because of that

Question 29

Iso abolishes baroreflexes around __ mac

Answer 29

1

Question 30

Iso cause circulatory collapse around __ mac

Answer 30

3

Question 31

Is iso implicated in "coronary steal"

Answer 31

No

Question 32

Will iso adversely affect renal or hepatic perfusion?

Answer 32

No

Question 33

Will iso raise your ICP?

Answer 33

Yes

Question 34

Can iso prolong the effects of muscle relaxants and thus allow a lower dose of vec to be used?

Answer 34

Yes

Question 35

Can iso trigger MH?

Answer 35

Yes

Question 36

What is uncoupling?

Answer 36

When iso decreases cerebral metabolic requirements but increases cerebral blood flow

Question 37

Can iso cause neuro degeneration in kids?

Answer 37

Yes

Question 38

Does iso contribute to post op cognitive dysfunction and accelerate Alzheimer's?

Answer 38

Yes

Question 39

Iso only undergoes 0.2% metabolism. What pathway is used and what are the outcomes?

Answer 39

``` Cytochrome p450 Trifluoroacetic acid Free fluoride Co2 Water ```

Question 40

Can iso cause hepatitis? What is the mediator?

Answer 40

Yes | Chlorine > Trifluoroacetic acid

Question 41

How much does iso cost compared to sevo and des?

Answer 41

1/5 or 20% of the cost of sevo and des