jaundice Flashcards
1
Q
what is Gilbert’s syndrome
A
isolated mild unconjugated hyperbilirubinaemia
2
Q
how to tell if there’s an obstruction in the bile ducts
A
USS
further CT and ERCP
MRI, MRCP
3
Q
Diagnostic pathway
A
History
examination
investigations - blood tests, imaging and biopsy
4
Q
jaundice history
A
pruritus, WL, pain, fevers, lethargy
due to other illness, alcohol, viral hep (IVDU, travel, blood transfusion, tattoos, sexual history), drug history and family history
5
Q
signs of CLD
A
spider naevi palmar erythema leuconycia dupytren's contracture caput medusae ascites gynaecomastia pallor
6
Q
LFTs
A
ALT INFLAMMATION AST ALP CHOLESTATIC GGT Albumin MET FUNC bilirubin INR
7
Q
Abnormal LFTs
A
NAFLD Alcohol/drugs/hep/biliary disease AI - hep, PBC, PSC Haemochromatosis Wilson disease
8
Q
other investigations
A
viral serology AI screen immunoglobulins ferritin a-1 trypsin copper caeruloplasmin others
9
Q
fibroscan - liver disease
A
transient elastography
measure of liver stiffness
correlates with fibrosis
10
Q
liver biopsy
A
confirm/establish diagnosis
staging
assess treatment/disease progress
