joint physiology Flashcards

1
Q

where do you find fibrous joints and what is there function

A

units bone and allows no movement eg skull

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2
Q

where do you find cartilaginous joints and what is there function

A

joins bones and allows limited movements eg vertebral disc and pubic symphysis

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3
Q

what is a synovial joint

A

articular (fibrous) capsule surrounding joint filled with synovial fluid

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4
Q

what is the inner part of the synovial capsule made of what covers articulating bones

A

synovial membrane - supplied with capillaries and lymphatics, contain synovial fibroblasts which produce fluid

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5
Q

what covers articulating bones in synovial joint

A

hyaline cartilage

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6
Q

what is the difference between compound and simple joints

A

compound have more than 1 articular surface eg elbows, simple joints have one articular surface eg fingers

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7
Q

what are the purposeful motion function of joints

A

stress distribution and shock absorption

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8
Q

how are synovial joints adapted for stability

A

shape of articular component, ligaments, synovial fluid

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9
Q

how are synovial joints lubricated

A

interstitial fluid, hyaluronic acid (mucin) and lubricin produced by synovium

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10
Q

what are the functions of synovial fluid

A

lubricates joint, allows movement, limits friction and wear and tear, provides nutrition for articular cartilage, supplies chondrocytes with O2 and removes CO2

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11
Q

what replenishes and absorbs synovial fluid

A

synovial membrane

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12
Q

synovial fluid is usually clear and colourless with few cells, what could change this

A

inflamm and septic arthritis = increased WBC. trauma and haemorrhagic arthritis = turns red

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13
Q

during movement, what happens to the viscosity and elasticity of synovial fluid

A

less viscosity and increased elasticity

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14
Q

what is the function of articular cartilage

A

low friction lubrication, distributes pressure on bones

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15
Q

what type of cartilage is articular cartilage made of

A

hyaline - spongy/ elastic

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16
Q

what is the majority of cartilage

A

ECM 98%, synthesised and degraded by chondrocytes (2%)

17
Q

how is articular cartilage nourished

A

synovial fluid

18
Q

what is the composition of the ECM in cartilage

A

70% water, 20% type II collagen, 10% proteoglycans

19
Q

what is the function of water in ECM

A

unevenly distributes (more at articular surfaces), decreased with age, helps with resilience, nutrition and lubrication

20
Q

what is the function of type II collagen in ECM

A

structure, strength and stiffness

21
Q

what is the function of proteoglycans in ECM

A

mostly in middle/ deep zones, compressive properties for load bearing

22
Q

what happens when the rate of ECM degradation> replenishment

A

disease

23
Q

what are catabolic factors of ECM turnover

A

stimulate proteolytic enzymes and inhibit proteoglycans eg TNF and IL1

24
Q

what are anabolic factors of ECM turnover

A

stimulates proteoglycans and counter effects IL1 eg tumour and insulin growth factors

25
Q

what are ECM markers of degradation

A

serum/ synovial keratin sulphate (increases with age and osteoarthritis)

26
Q

what happens to cartilage with reduced ECM turnover

A

cartilage breakdown and erosion