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What were the primary findings of a study by Kemp et al comparing liver sampling techniques in dogs? 


JVIM 2015 29.

  • Liver specimens collected by punch, cup and needle were compared to samples collected at necropsy
  • Diagnosis in 66% of needle samples, 60% of cup samples and 69% of punch samples were in agreement with necropsy samples; no significant difference between the modalities


What were the primary findings of a study by Wallisch and Trepanier regarding the incidence, timing and risk factors of azathioprine hepatotoxicosis in dogs? 


JVIM 2015 29.

  • Hepatotoxicosis was seen in 15% of dogs, with median onset of 14 days
  • Median 9-fold increase in ALT and 8-fold increase in ALP which stabilized or resolved with drug discontinuation/dose reduction
  • Thrombocytopenia/neutropenia seen in 8% of dogs with CBC follow-up, with median onset time of 53 days


What were the findings of a study by Lidbury et al regarding putative precipitating factors for hepatic encephalopathy in dogs (118 cases)?


Javma 2015 247

  • Looked for an association between SIRS, GI hemorrhage, dietary indiscretion, constipation, furosemide treatment, azotemia, hypokalemia, hyponatremia, alkalosis and hyperammonemia--none identified
  • Treatment for presumed HE prior to hospital admission were significantly less likely to have clinical signs of disease at admission


What were the findings of a study by Greenhalgh et al regarding long term survival and quality of life in dogs with clinical signs associated with a congenital portosystemic shunt after surgical or medical treatment? 


JAVMA 2014 245. 

  • Surgical treatment of CPSS in dogs resulted in significantly improved survival rate and lower frequency of ongoing clinical signs compared to medical management
  • Age at diagnosis did not affect survival rate and should not influence treatment choice