Juxta Glomerular Apparatus Flashcards
(15 cards)
What are the components of the juxtaglomerular apparatus?
Juxtaglomerular (JG) cells, macula densa, mesangial/lacis/supporting cells/polkissen cells
Composition of macula densa?
Modified tall columnar cells
Where is the macula densa located?
DCT
What is the function of juxtaglomerular (JG) cells?
Secretion of renin
Function of Macula densa
TG feedback
TG feedback is mediated by ?
Adenosine
Phases of Tubular injury and recovery
1) Phase of tubular injury
2) Phase of TG feedback
3) Phase of recovery
What are all the findings in TG feedback
Reduced GFR
Increased S.Creatinine
Hyperkalemia
Metabolic acidosis
When macula densa senses reduced Cl Na K dilatation of afferent arteriole occur to increase GFR
This process is mediated by?
Prostaglandins
Composition of JG cells
Granular cells
Site of JG cells
Tunica Media of
Afferent arteriole > Efferent arteriole
Mechanism that activate JG cells to release Renin
Reduced renal Perfusion
Prostaglandins
Beta 1 receptor activation
Renal circulation
1) Renal artery
2) 5 segmental arteries (4 ant and 1posterior)
3) interiobar artery
4) Arcuate artery
5) interbbular/corticalradial artery
6) Afferent arteriole
7) Supplies glomerular capillari plexus
8) Efferent arteriole
9) Peritubular Capillary plexus
10) Blood supply to medula(Mediated by vasa recta)
11) Descending limb of vasa recta
12) Ascending limb of vasa recta
13) Renal vein
14) IVC
Structure sandwiches between two capillary plexus
Efferent arteriole
It is situated between glomerular capillary plexus and Peritubular Capillary plexus
Causes of AKI
1) Outside kidney
Prerenal cause
Post renal cause
2) Inside kidney
Acute tubular injury
Acute interstitial nephritis
