Urine Analysis Flashcards

(35 cards)

1
Q

Which urine sample is preferred for analysis?

A

Second morning urine sample using midstream technique

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2
Q

When should urine analysis be performed after collection?

A

Within 2–4 hours at room temperature

But ph should be checked imediately

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3
Q

What preservatives can be used for urine?

A

Formaldehyde and glutaraldehyde.

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4
Q

How should urine be stored for delayed analysis?

A

At 2°C - 8°C for up to 12 hours.

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5
Q

What should be avoided before urine collection?

A

Strenuous physical activity for 72 hours

Urine collection should be avoided during Menstruation

For catheterised patients: use fresh urine, avoid urobags

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6
Q

Why should pH be checked immediately in urine?

A

pH increases over time can affect the analysis. As time goes by the urine become more and more alkaline

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7
Q

What drug causes pink-colored urine?

A

1) Desferrioxamine
2) Beetroot ingestion.

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8
Q

What drugs can darken urine upon standing?

A

Imipenem + cilastatin

Imepenam is cabapenam group of antibiotics and cilastatin is dehydropeptidase inhibitor which prevents in breaking down of imepenam and ensure prolonged antibiotic effect

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9
Q

What drug can cause green-colored urine?

A

Triamterene (an ENaC blocker).

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10
Q

Which medications can turn urine brown?

A

Nitrofurantoin

It is given in non complicated uti

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11
Q

What causes orange-colored urine?

A

Rifampicin, Entacapone (COMT inhibitor).

COMT inhibitors are used to treat S/E of levodopa in parkinsonism

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12
Q

What does pungent-smelling urine indicate?

A

Infection (due to ammonia produced by bacteria).

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13
Q

Musty or mousy odor in urine suggests?

A

Phenylketonuria (PKU).

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14
Q

What condition is indicated by curry or maple syrup smell in urine?

A

Maple Syrup Urine Disease (MSUD).

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15
Q

What conditions are associated with sweaty feet odor in urine?

A

Isovaleric acidemia

Glutaric aciduria type II

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16
Q

What condition is associated with a cabbage-like odor in urine?

A

Tyrosinemia type I

17
Q

What condition is indicated by a rancid butter smell in urine?

A

Tyrosinemia type I

18
Q

What does a cat urine smell in urine suggest?

A

Multiple carboxylase deficiency (MCD)

19
Q

What condition is indicated by an acid smell in urine?

A

Methylmalonic acidemia (MMA)

20
Q

Fishy smelling urine is characteristic of what condition?

A

Trimethylaminuria

21
Q

Sulfurous odor in urine is associated with which condition?

22
Q

Sweet-smelling urine is indicative of which condition?

A

Beta-ketothiolase deficiency

23
Q

A swimming pool-like smell in urine suggests what condition?

A

Hawkinsinuria

24
Q

What is the normal pH range of urine?

A

4.0 – 4.5 (acidic)

25
What is the normal specific gravity of urine?
1.020 – 1.040
26
What is the normal osmolality range of urine?
800 – 900 mOsm/kg
27
Main part of tubule involved in acidification of urine
Cortical collecting duct
28
What cells of Cortical collecting duct helps in acidification of urine ?
Alpha I Cells
29
What pumps in Alpha I Cells helps in acidification of urine
H+ ATPase pump H+ K+ ATPase pump
30
Factors or components involved in concentration of urine are ?
1) ADH 2) Medullary interstitium (increase osmolality d/t urea) 3) Vasa recta
31
What defines RTA type 1 in the context of urine evaluation?
Urine pH > 5.5 for 3 days with normal RFT.
32
What is the significance of urine specific gravity < 1.005 and urine osmolality <200mosm/kg ?
It indicates dilute urine, often seen in conditions like Diabetes Insipidus
33
What is Isosthenuria?
A condition where urine osmolality equals plasma osmolality, indicating kidney's inability to concentrate or dilute urine.
34
What are some conditions associated with abnormal urine parameters like isosthenuria?
Acute Tubular Necrosis (ATN) Chronic Tubulo-Interstitial Disease (CTID)
35
Please refer marrow notes for further chapterrr