Flashcards in Katzung 12th ed - Chapter 49 - Acyclovir (2) Deck (7):
What is the basic structure of acyclovir?
It is a guanosine analogue.
Name three viruses that are most susceptible to acyclovir.
HSV-1, HSV-2, VZV.
What are some clinical uses of acyclovir?
Genital herpes, Herpes encephalitis, Shingles.
Describe the toxicities of acyclovir.
Acyclovir is well-tolerated. It is sold over-the-counter as topical Zovirax. There can be nausea, vomiting, diarrhoea, headache.
Clearance of acyclovir?
Renal. Glomerular filtration and tubular secretion.
Half-life of acyclovir?